Microtubule-Associated Protein 1 Light Chain 3 gamma (MAP1LC3C) antibody

Details for Product No. ABIN271665
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Synonyms ATG8J, LC3C, MAP1LC3C, MGC154878
(27), (13), (12), (12), (12), (1), (1)
(22), (3), (1), (1)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
(13), (10), (8), (6), (4), (3), (1), (1)
Pubmed 5 references available
Catalog no. ABIN271665
Quantity 0.1 mL
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Immunogen A synthetic peptide corresponding to the N-terminal of human MAP1LC3 C(MAP1LC3C, APG8c) conjugated to Blue Carrier Protein has been used as theimmunogen. The peptide is homologous with the corresponding sequence deriven fromMAP1LC3 C (MAP1LC3C, APG8c) protein in Macaca mulatta (monkey) and Canisfamiliaris (dog).
Specificity IHC and WB confirmed the specificity for MAP1LC3 C (MAP1LC3C, APG8c). Thisantibody should recognise MAP1LC3 C only and not the other forms MAP1LC3A andMAP1LC3B. Species Reactivity: Human, other species have not yet been tested. Localization: Accession Number: MLP3C_HUMAN.
Cross-Reactivity Human
Alternative Name MAP1LC3C
Background FUNCTION: Probably involved in formation of autophagosomal vacuoles(autophagosomes). SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associatewith MAP1A and MAP1B proteins. SUBCELLULAR LOCATION: LC3-I: Cytoplasm.LC3-II: Intracytoplasmic membrane, lipid-anchor. LC3-II binds to the autophagicmembranes. TISSUE SPECIFICITY: Most abundant in placenta, lung and ovary. PTM:The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I.This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipidto form the membrane-bound form, LC3-II. SIMILARITY: Belongs to the MAP1 LC3family. Alternate Names: anti-Microtubule-associated proteins 1A/1B light chain 3C antibody,anti-Microtubule-associated protein 1 light chain 3 gamma antibody,anti-MAP1A/MAP1B LC3 C antibody, anti-MAP1A/1B light chain 3 C antibody,anti-MAP1 light chain 3-like protein 3 antibody, anti-Autophagy-related protein LC3 Cantibody, anti-Autophagy-related ubiquitin-like modifier LC3 C antibody, anti-APG8c,biosensis. GENE NAME: MAP1LC3C antibody. Related Diseases: Autophagy
Gene ID 440738
Application Notes IHC, immunofluorescence, WB. A dilution of 1:100 to 1:1000 dilution is recommendedfor these applications. The optimal working dilution should be determined by the enduser.
Restrictions For Research Use only
Format Liquid
Buffer Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Preservative: No Preservative.
General Tanida, Ueno, Kominami: "LC3 conjugation system in mammalian autophagy." in: The international journal of biochemistry & cell biology, Vol. 36, Issue 12, pp. 2503-18, 2004 (PubMed).

Levine: "Eating oneself and uninvited guests: autophagy-related pathways in cellular defense." in: Cell, Vol. 120, Issue 2, pp. 159-62, 2005 (PubMed).

Lum, DeBerardinis, Thompson: "Autophagy in metazoans: cell survival in the land of plenty." in: Nature reviews. Molecular cell biology, Vol. 6, Issue 6, pp. 439-48, 2005 (PubMed).

Baehrecke: "Autophagy: dual roles in life and death?" in: Nature reviews. Molecular cell biology, Vol. 6, Issue 6, pp. 505-10, 2005 (PubMed).

Greenberg: "Degrade or die: a dual function for autophagy in the plant immune response." in: Developmental cell, Vol. 8, Issue 6, pp. 799-801, 2005 (PubMed).

Hosts (22), (3), (1), (1)
Reactivities (27), (13), (12), (12), (12), (1), (1)
Applications (13), (10), (8), (6), (4), (3), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2), (2), (2), (1), (1)
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