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Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (Extracellular Domain) antibody

Details for Product No. ABIN271673
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Antigen
Synonyms GP145-TrkB, TRKB, trk-B, Tkrb, trkB, AI848316, C030027L06Rik, RATTRKB1, TRKB1, Trk-B, TrkB, trkb, trkb-b, xtrkb, si:ch211-220b11.1, trkB2, NTRK2, ntrk2, gp145-trkb
Epitope
Extracellular Domain
(35), (33), (17), (16), (14), (8), (7), (5), (5), (5), (5), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus)
(207), (152), (151), (27), (25), (24), (12), (1), (1)
Host
Rabbit
(204), (14), (6), (5), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1), (1)
Application
ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))
(152), (83), (83), (40), (31), (27), (9), (4), (4), (3), (2), (1)
Pubmed 1 reference available
Quantity 0.1 mL
Shipping to United States (Change)
Catalog No. ABIN271673
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  • +1 404 474 4654
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Immunogen Extracellular domain of glycosylated mouse Trk B protein produced in CHO cells was used as the immunogen. As shown for similar antisera, it is anticipated that this antibody will block the TrkB receptor binding of corresponding neurotrophin ligand.
Specificity Specificity was demonstrated by immunohistochemistry. This was used to stain cryostat sections of the rat peripheral sensory ganglia.
Purification Whole antisera
Alternative Name TrkB
Background FUNCTION: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 andneurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/ormaintenance of the nervous system. This is a tyrosine-protein kinase receptor. Knownsubstrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosinephosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity)and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1.SUBCELLULAR LOCATION: Membrane, single-pass type I membrane protein.ALTERNATIVE PRODUCTS: 4 named isoforms produced by alternative splicing.Additional isoforms seem to exist. TISSUE SPECIFICITY: The different forms aredifferentially expressed in various cell types. PTM: Ligand-mediatedauto-phosphorylation. SIMILARITY: Belongs to the Tyr protein kinase family. Insulinreceptor subfamily. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like)domains. SIMILARITY: Contains 2 LRR (leucine-rich) repeats. SIMILARITY: Contains 1protein kinase domain. Alternate Names: anti-BDNF/NT-3 growth factors receptor antibody, anti-Neurotrophic tyrosine kinasereceptor type 2 antibody, anti-TrkB tyrosine kinase antibody,anti-GP145-TrkB/GP95-TrkB antibody, anti-Trk-B. GENE NAME: Ntrk2 antibody,anti-Trkb antibody. Related Diseases: Neurotrophic Receptors
Gene Symbol: NTRK2
Gene ID 4915, 25054
Research Area Cancer
Application Notes 1-site ELISA (1:10000 dilution). The optimal working dilution should be determined by the end user.
Recommended dilutions: ELISA 1:10000 (1-site), Immunohistochemistry-Frozen 1:1000-1:3000, Immunohistochemistry
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add diH20 to desired concentration.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Desmet, Peeper: "The neurotrophic receptor TrkB: a drug target in anti-cancer therapy?" in: Cellular and molecular life sciences : CMLS, Vol. 63, Issue 7-8, pp. 755-9, 2006 (PubMed).

Hosts (204), (14), (6), (5), (2)
Reactivities (207), (152), (151), (27), (25), (24), (12), (1), (1)
Applications (152), (83), (83), (40), (31), (27), (9), (4), (4), (3), (2), (1)
Conjugates (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1), (1)
Epitopes (35), (33), (17), (16), (14), (8), (7), (5), (5), (5), (5), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN271673
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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