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Details for Product No. ABIN271673

Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) antibody

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Synonyms GP145-TrkB, TRKB, trk-B, Tkrb, trkB, AI848316, C030027L06Rik, RATTRKB1, TRKB1, Trk-B, TrkB, trkb, trkb-b, xtrkb, si:ch211-220b11.1, trkB2, NTRK2, ntrk2, gp145-trkb
»Alternatives Mouse (Murine), Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA
Pubmed 1 reference available
Catalog no. ABIN271673
Quantity 0.1 mL
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Immunogen Extracellular domain of glycosylated mouse Trk B protein produced in CHO cells wasused as the immunogen. As shown for similar antisera, it is anticipated that this antibodywill block the TrkB receptor binding of corresponding neurotrophin ligand.
Specificity Specificity was demonstrated by immunohistochemistry. This antibody was used to staincryostat sections of the rat peripheral sensory ganglia. Species Reactivity: Reacts with rat and mouse TrkB. Other species have not yet been tested. Localization: Accession Number: NTRK2_MOUSE.
Alternative Name TrkB
Background FUNCTION: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 andneurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/ormaintenance of the nervous system. This is a tyrosine-protein kinase receptor. Knownsubstrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosinephosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity)and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1.SUBCELLULAR LOCATION: Membrane, single-pass type I membrane protein.ALTERNATIVE PRODUCTS: 4 named isoforms produced by alternative splicing.Additional isoforms seem to exist. TISSUE SPECIFICITY: The different forms aredifferentially expressed in various cell types. PTM: Ligand-mediatedauto-phosphorylation. SIMILARITY: Belongs to the Tyr protein kinase family. Insulinreceptor subfamily. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like)domains. SIMILARITY: Contains 2 LRR (leucine-rich) repeats. SIMILARITY: Contains 1protein kinase domain. Alternate Names: anti-BDNF/NT-3 growth factors receptor antibody, anti-Neurotrophic tyrosine kinasereceptor type 2 antibody, anti-TrkB tyrosine kinase antibody,anti-GP145-TrkB/GP95-TrkB antibody, anti-Trk-B. GENE NAME: Ntrk2 antibody,anti-Trkb antibody. Related Diseases: Neurotrophic Receptors
Gene ID 4915, 25054
Research Area Cancer
Application Notes IHC, 1-site ELISA (1:10000 dilution). A dilution of 1:1000 to 1:3000 is recommended forIHC. The optimal working dilution should be determined by the end user.
Restrictions For Research Use only
Buffer Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Preservative: No Preservative.
Desmet, Peeper: "The neurotrophic receptor TrkB: a drug target in anti-cancer therapy?" in: Cellular and molecular life sciences : CMLS, Vol. 63, Issue 7-8, pp. 755-9, 2006 (PubMed).

Alternatives for antigen "Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2)", type "Antibodies"
Hosts (178), (13), (7), (4), (4)
Reactivities (176), (148), (144), (27), (25), (24), (12), (1)
Applications (135), (66), (63), (40), (39), (26), (8), (8), (5), (3), (2), (2), (1)
Conjugates (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (29), (29), (17), (15), (13), (6), (6), (6), (5), (5), (4), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)