Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B) (N-Term) antibody

Details for Product No. ABIN271679
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(26), (11), (9), (9), (6), (6), (6), (5), (5), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(64), (55), (32), (26), (23), (20), (20), (18), (12), (5), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mL
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Catalog No. ABIN271679
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Immunogen A synthetic peptide (FEQRVEDVRLIC) corresponding to the N-terminal of human MAP1LC3 B (MAP1LC3B, APG8b) protein conjugated to Blue Carrier Protein has been used as the immunogen.
Cross-Reactivity (Details) Expected cross-reactivity based on antigen sequence identity: Mouse (100%), rat,(100%). The Other species not yet tested.
Purification Whole antisera
Alternative Name LC3B
Background FUNCTION: Probably involved in formation of autophagosomal vacuoles(autophagosomes). SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associatewith MAP1A and MAP1B proteins. INTERACTION: Q9H1J2:-, NbExp=1,IntAct=EBI-373144, EBI-372073, SUBCELLULAR LOCATION: LC3-I: Cytoplasm.LC3-II: Intracytoplasmic membrane, lipid-anchor. Cytoplasmic vesicle, autophagosome,autophagosomal membrane, lipid-anchor. Note=LC3-II binds to the autophagicmembranes. TISSUE SPECIFICITY: Most abundant in heart, brain, skeletal muscle andtestis. Little expression observed in liver. PTM: The precursor molecule is cleaved byAPG4B/ATG4B to form LC3-I. This is activated by APG7L/ATG7, transferred to ATG3and conjugated to phospholipid to form LC3-II. SIMILARITY: Belongs to the MAP1 LC3family. Alternate Names: anti-Microtubule-associated proteins 1A/1B light chain 3B antibody,anti-Microtubule-associated protein 1 light chain 3 beta antibody, anti-MAP1A/MAP1BLC3 B antibody, anti-MAP1A/1B light chain 3 B antibody, anti-MAP1 light chain 3-likeprotein 2 antibody, anti-Autophagy-related protein LC3 B antibody,anti-Autophagy-related ubiquitin-like modifier LC3 B antibody, anti-APG8b, biosensis.GENE NAME: MAP1LC3B antibody, anti-MAP1ALC3 antibody. Related Diseases: Autophagy
Gene Symbol: MAP1LC3B
Gene ID 81631, 64862
Research Area Cancer, Autophagy, Cytoskeleton
Application Notes CAUTION: Ref.3 has shown that the protein is cleaved at Lys-121 but Ref.5 has shown that the cleavage site is at Gly-119 as in other mammalian orthologs.
Recommended dilutions: Western Blot 1:100-1:1000, Immunohistochemistry-Paraffin 1:100-1:1000, Immunocytochemistry/Immunofluorescence 1:100-1:1000, Immunohistochemistry
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL diH20 to reconstitute.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Difilippantonio, Chen, Pietas et al.: "Gene expression profiles in human non-small and small-cell lung cancers." in: European journal of cancer (Oxford, England : 1990), Vol. 39, Issue 13, pp. 1936-47, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Yang, Song, Peng et al.: "The gene expression profiling of sporadic pheochromocytoma and novel full-length cDNAs cloning." in: Endocrine-related cancer, Vol. 10, Issue 4, pp. 621-7, 2004 (PubMed).

Tanida, Ueno, Kominami: "LC3 conjugation system in mammalian autophagy." in: The international journal of biochemistry & cell biology, Vol. 36, Issue 12, pp. 2503-18, 2004 (PubMed).

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