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Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B) (N-Term) antibody

Details for Product No. ABIN271679
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Antigen
Epitope
N-Term
(25), (11), (9), (9), (6), (6), (6), (5), (5), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(118), (49), (39), (25), (25), (14), (14), (4), (2), (1), (1), (1)
Host
Rabbit
(107), (14)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (7), (7), (7), (6), (5), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(63), (61), (32), (23), (23), (20), (17), (17), (11), (4), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mL
Shipping to United States (Change)
Catalog No. ABIN271679
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  • +1 404 474 4654
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Immunogen A synthetic peptide (FEQRVEDVRLIC) corresponding to the N-terminal of human MAP1LC3 B (MAP1LC3B, APG8b) protein conjugated to Blue Carrier Protein has been used as the immunogen.
Cross-Reactivity (Details) Expected cross-reactivity based on antigen sequence identity: Mouse (100%), rat,(100%). The Other species not yet tested.
Purification Whole antisera
Alternative Name LC3B
Background FUNCTION: Probably involved in formation of autophagosomal vacuoles(autophagosomes). SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associatewith MAP1A and MAP1B proteins. INTERACTION: Q9H1J2:-, NbExp=1,IntAct=EBI-373144, EBI-372073, SUBCELLULAR LOCATION: LC3-I: Cytoplasm.LC3-II: Intracytoplasmic membrane, lipid-anchor. Cytoplasmic vesicle, autophagosome,autophagosomal membrane, lipid-anchor. Note=LC3-II binds to the autophagicmembranes. TISSUE SPECIFICITY: Most abundant in heart, brain, skeletal muscle andtestis. Little expression observed in liver. PTM: The precursor molecule is cleaved byAPG4B/ATG4B to form LC3-I. This is activated by APG7L/ATG7, transferred to ATG3and conjugated to phospholipid to form LC3-II. SIMILARITY: Belongs to the MAP1 LC3family. Alternate Names: anti-Microtubule-associated proteins 1A/1B light chain 3B antibody,anti-Microtubule-associated protein 1 light chain 3 beta antibody, anti-MAP1A/MAP1BLC3 B antibody, anti-MAP1A/1B light chain 3 B antibody, anti-MAP1 light chain 3-likeprotein 2 antibody, anti-Autophagy-related protein LC3 B antibody,anti-Autophagy-related ubiquitin-like modifier LC3 B antibody, anti-APG8b, biosensis.GENE NAME: MAP1LC3B antibody, anti-MAP1ALC3 antibody. Related Diseases: Autophagy
Gene Symbol: MAP1LC3B
Gene ID 81631, 64862
Research Area Cancer, Autophagy, Cytoskeleton
Application Notes CAUTION: Ref.3 has shown that the protein is cleaved at Lys-121 but Ref.5 has shown that the cleavage site is at Gly-119 as in other mammalian orthologs.
Recommended dilutions: Western Blot 1:100-1:1000, Immunohistochemistry-Paraffin 1:100-1:1000, Immunocytochemistry/Immunofluorescence 1:100-1:1000, Immunohistochemistry
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL diH20 to reconstitute.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Difilippantonio, Chen, Pietas et al.: "Gene expression profiles in human non-small and small-cell lung cancers." in: European journal of cancer (Oxford, England : 1990), Vol. 39, Issue 13, pp. 1936-47, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Yang, Song, Peng et al.: "The gene expression profiling of sporadic pheochromocytoma and novel full-length cDNAs cloning." in: Endocrine-related cancer, Vol. 10, Issue 4, pp. 621-7, 2004 (PubMed).

Tanida, Ueno, Kominami: "LC3 conjugation system in mammalian autophagy." in: The international journal of biochemistry & cell biology, Vol. 36, Issue 12, pp. 2503-18, 2004 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN271679
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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