ATG4 Autophagy Related 4 Homolog B (S. Cerevisiae) (ATG4B) (C-Term) antibody

Details for Product No. ABIN271681
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(15), (12), (9), (8), (7), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(90), (35), (17), (15), (14), (14), (2), (2), (2), (1), (1)
(87), (3), (1)
(4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC)
(69), (31), (27), (20), (15), (2), (2), (2), (1)
Pubmed 1 reference available
Quantity 0.1 mL
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Catalog No. ABIN271681
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Immunogen A synthetic peptide (CLERFFDSEDED) corresponding to the C-terminus of human ATG4B protein conjugated to Blue Carrier Protein has been used as the immunogen.
Specificity IHC, WB and ELISA confirmed the specificity for ATG4B.
Cross-Reactivity (Details) The peptide is homologous with the corresponding sequence derived from of ATG4B protein in mouse,rat.
Purification IgG purified
Alternative Name APG4B / ATG4B
Background FUNCTION: Cysteine protease required for autophagy, which cleaves the C-terminalpart of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. Asubpopulation of form I is subsequently converted to a smaller form (form II). Form II,with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine(PE)-conjugated form, and has the capacity for the binding to autophagosomes.ENZYME REGULATION: Inhibited by N-ethylmaleimide. SUBCELLULAR LOCATION:Cytoplasm (Probable). ALTERNATIVE PRODUCTS: 5 named isoforms produced byalternative splicing. Alternate Names: anti-Cysteine protease ATG4B antibody, anti-Autophagy-related protein 4 homolog Bantibody, anti-hAPG4B antibody, anti-Autophagin-1 antibody, anti-Autophagy-relatedcysteine endopeptidase 1 antibody, anti-AUT-like 1 cysteine endopeptidase, biosensis.GENE NAME: ATG4B antibody, anti-APG4B antibody, anti-AUTL1 antibody,anti-KIAA0943 antibody. Related Diseases: Autophagy
Gene Symbol: ATG4B
Gene ID 23192, 316640
Application Notes Recommended dilutions: ELISA, Immunocytochemistry/Immunofluorescence 1:100-1:2000, Immunohistochemistry 1:100-1:2000, Western Blot 1:100-1:2000
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water.
Buffer Lyophilized whole serum.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Mariño, Uría, Puente et al.: "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy." in: The Journal of biological chemistry, Vol. 278, Issue 6, pp. 3671-8, 2003 (PubMed).

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