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Details for Product No. ABIN271682

ATG16 Autophagy Related 16-Like 1 (S. Cerevisiae) (ATG16L1) antibody

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Antigen
Synonyms APG16L, ATG16A, ATG16L, IBD10, WDR30, 1500009K01Rik, Apg16l, Atg16l, Wdr30, atg16, atg16l
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN271682
Quantity 0.1 mL
Price
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Immunogen A synthetic peptide corresponding to the N-terminal of human ATG16-L1 proteinconjugated to Blue Carrier Protein has been used as the immunogen. The peptide ishomologous with the corresponding sequence derived from isoform alpha of ATG16-Lprotein in mouse, rat, S. cerevisiae, Macaca mulatta (monkey) and Canis familiaris(dog).
Specificity IHC, WB and ELISA confirmed the specificity for ATG16 L1. Species Reactivity: Human, rat. Other species not yet tested.
Cross-Reactivity Human, Rat (Rattus)
Alternative Name APG16L / ATG16L1
Background FUNCTION: Plays an essential role in autophagy. SUBUNIT: Homooligomer. Interactswith ATG5. Part of either the minor and major complexes respectively composed of 4sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1(800 kDa). SUBCELLULAR LOCATION: Cytoplasm. Preautophagosomal structure,preautophagosomal structure membrane, peripheral membrane protein. Localized topreautophagosomal structure (PAS) where it is involved in the membrane targeting ofATG5. ALTERNATIVE PRODUCTS: 5 named isoforms produced by alternative splicing.SIMILARITY: Belongs to the WD repeat ATG16 family. SIMILARITY: Contains 7 WDrepeats. Alternate Names: biosensis. Related Diseases: Autophagy
Gene ID 55054, 363278
Application Notes IHC, immunofluorescence, WB. A dilution of 1:100 to 1:3000 dilution is recommendedfor these applications. The optimal dilution should be determined by the end user. Eosinophils seem to be stained using Rabbit antibody to APG16 L1 (ATG16L1): wholeserum (R-158-100). The cells stained for APG16 L1 (ATG16L1) appear in red. The cellswere then counter stained with Hoechst Dye (blue colour). Here, the merged picture ispresented.
Restrictions For Research Use only
Buffer Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Preservative: No Preservative.
Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Zheng, Ji, Li et al.: "Cloning and analysis of human Apg16L." in: DNA sequence : the journal of DNA sequencing and mapping, Vol. 15, Issue 4, pp. 303-5, 2004 (PubMed).

Alternatives for antigen "ATG16 Autophagy Related 16-Like 1 (S. Cerevisiae) (ATG16L1)", type "Antibodies"
Hosts (124), (7), (3), (2)
Reactivities (121), (75), (58), (39), (15), (13), (11), (2), (1), (1), (1), (1), (1)
Applications (98), (37), (30), (25), (18), (12), (5), (4), (2), (2), (2)
Conjugates (7), (7), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2)
Epitopes (14), (14), (14), (12), (9), (7), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
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