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Peroxiredoxin 6 (PRDX6) antibody

Details for Product No. ABIN271691
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Antigen
Synonyms
1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29, 1-cysPrx, 9430088D19Rik, AA690119, Aop2, Aop2-rs3, Brp-12, CC26, CP-3, GPx, Ltw-4, Ltw4, Lvtw-4, NSGP, ORF06, Prdx5, Prdx6-rs3, mKIAA0106, zgc:73360, PHGPX, aop2, ... show more
1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29, 1-cysPrx, 9430088D19Rik, AA690119, Aop2, Aop2-rs3, Brp-12, CC26, CP-3, GPx, Ltw-4, Ltw4, Lvtw-4, NSGP, ORF06, Prdx5, Prdx6-rs3, mKIAA0106, zgc:73360, PHGPX, aop2, prx-6, prx6, prdx6, MGC64522 show less
Reactivity
Human
(80), (27), (20), (4), (4), (2), (2), (2), (1)
Host
Rabbit
(56), (32), (3), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (2), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(85), (62), (35), (25), (14), (13), (13), (10), (8)
Pubmed 9 references available
Quantity 0.1 mL
Shipping to United States (Change)
Catalog No. ABIN271691
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  • +1 404 474 4654
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Immunogen Rat recombinant Peroxiredoxin-6. The sequence is homologous in human and mouse peroxiredoxin-6.
Specificity This has been shown to be specific for Peroxiredoxin-6 protein.
Cross-Reactivity (Details) Other species not yet tested.
Purification Whole antisera
Alternative Name Peroxiredoxin-6 (PRDX6)
Background FUNCTION: Involved in redox regulation of the cell. Can reduce H(2)O(2) and shortchain organic, fatty acid, and phospholipid hydroperoxides. May play a role in theregulation of phospholipid turnover as well as in protection against oxidative injury.CATALYTIC ACTIVITY: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. SUBUNIT:Homotetramer. May interact with HTR2A. SUBCELLULAR LOCATION: Cytoplasm.Lysosome. Note=Also found in lung secretory organelles. MISCELLANEOUS: Theactive site is the redox-active Cys-47 oxidized to Cys-SOH. Cys-SOH may rapidly reactwith a Cys-SH of the other subunit to form an intermolecular disulfide with a concomitanthomodimer formation. The enzyme may be subsequently regenerated by reduction ofthe disulfide by thioredoxin . MISCELLANEOUS: Irreversibly inactivated byoveroxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress. SIMILARITY: Belongs tothe ahpC/TSA family. Rehydrin subfamily. Alternate Names: anti-Non-selenium glutathione peroxidase antibody, anti-antioxidant protein 2 antibody,anti-1-Cys peroxiredoxin antibody, anti-1-Cys PRX antibody, anti-Acidiccalcium-independent phospholipase A2 antibody, anti-NSGPx antibody,anti-Thiol-specific antioxidant protein. GENE NAME: Prdx6 antibody, anti-Aipla2antibody, anti-Aop2 antibody, anti-Tsa antibody, biosensis. Related Diseases: Antioxidant Enzymes
Gene Symbol: PRDX6
Gene ID 9588, 11758, 94167
Application Notes IHC-P, WB, ELISA. This antibody works superbly in Immunohistochemistry on frozen or paraffin embedded tissues. Antigen retrieval has been used in testing but may not be necessary.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add diH20 to desired concentration.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Nagase, Miyajima, Tanaka et al.: "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 2, Issue 1, pp. 37-43, 1995 (PubMed).

Kim, Sundaresh, Feinstein et al.: "Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein." in: The Journal of biological chemistry, Vol. 272, Issue 4, pp. 2542-50, 1997 (PubMed).

Frank, Munz, Werner: "The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene." in: Oncogene, Vol. 14, Issue 8, pp. 915-21, 1997 (PubMed).

Kang, Baines, Rhee: "Characterization of a mammalian peroxiredoxin that contains one conserved cysteine." in: The Journal of biological chemistry, Vol. 273, Issue 11, pp. 6303-11, 1998 (PubMed).

Choi, Kang, Yang et al.: "Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution." in: Nature structural biology, Vol. 5, Issue 5, pp. 400-6, 1998 (PubMed).

Power, Nicholas: "Immunohistochemical localization and characterization of a rat Clara cell 26-kDa protein (CC26) with similarities to glutathione peroxidase and phospholipase A2." in: Experimental lung research, Vol. 25, Issue 5, pp. 379-92, 1999 (PubMed).

Gevaert, Goethals, Martens et al.: "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." in: Nature biotechnology, Vol. 21, Issue 5, pp. 566-9, 2003 (PubMed).

Rush, Moritz, Lee et al.: "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." in: Nature biotechnology, Vol. 23, Issue 1, pp. 94-101, 2005 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Hosts (56), (32), (3), (2)
Reactivities (80), (27), (20), (4), (4), (2), (2), (2), (1)
Applications (85), (62), (35), (25), (14), (13), (13), (10), (8)
Conjugates (3), (2), (2), (1), (1), (1), (1), (1)
Epitopes (10), (7), (6), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN271691
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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