Glial Cell Derived Neurotrophic Factor (GDNF) antibody

Antigen: Glial Cell Derived Neurotrophic Factor (GDNF)

Synonyms: GDNF, AI385739, gdnf

Clonality: Polyclonal

Host: Sheep

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN271704

Additional Information

Alternative name: GDNF

Gene ID: 2668, 14573, 25453

Immunogen: Recombinant human GDNF.

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Description: GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discoveredas a potent survival factor for midbrain dopaminergic neurons and was then shown torescue these neurons in animal models of Parkinson's disease. GDNF is about 100times more efficient survival factor for spinal motor neurons than the neurotrophins. ,FUNCTION: Neurotrophic factor that enhances survival and morphologicaldifferentiation of dopaminergic neurons and increases their high-affinity dopamineuptake. SUBUNIT: Homodimer, disulfide-linked. SUBCELLULAR LOCATION: Secretedprotein. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternativesplicing. , DISEASE: Defects in GDNF may be a cause of Hirschsprung disease(HSCR). In association with mutations of RET gene, defects in GDNF may be involvedin Hirschsprung disease. This genetic disorder of neural crest development ischaracterized by the absence of intramural ganglion cells in the hindgut, often resultingin intestinal obstruction. DISEASE: Defects in GDNF are a cause of congenital centralhypoventilation syndrome (CCHS), also known as congenital failure of autonomiccontrol or Ondine curse. CCHS is a rare disorder characterized by abnormal control ofrespiration in the absence of neuromuscular or lung disease, or an identifiable brainstem lesion. A deficiency in autonomic control of respiration results in inadequate ornegligible ventilatory and arousal responses to hypercapnia and hypoxemia.SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily. Alternate Names: anti-Glial cell line-derived neurotrophic factor antibody, anti-Astrocyte-derived trophicfactor 1 antibody, anti-ATF-1 antibody. Related Diseases: Neurotrophic Factors

Specificity: No cross reativity with NTN has been observed in western blot analysis. Species Reactivity: Reacts with human, mouse and rat. Localization: Accession Number: GDNF_HUMAN.

Application Details

Application Notes: Suggested working dilutions: Western Blot 1:1000 to 1:3000

Buffer: Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Preservative: No Preservative.

Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Research Area: Organogenesis, Growth Factors

Restrictions: For Research Use only

Publications

Lin, Doherty, Lile et al.: "GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons." in: Science (New York, N.Y.), Vol. 260, Issue 5111, pp. 1130-2, 1993 (PubMed).