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SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) antibody

Details for Product No. ABIN271727
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Antigen
Reactivity
Human
(140), (68), (63), (24), (23), (12), (11), (2), (1), (1), (1), (1)
Host
Sheep
(123), (22), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (6), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(117), (54), (43), (32), (29), (28), (25), (20), (4), (3), (1), (1)
Pubmed 5 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN271727
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Immunogen A synthetic peptide (AKPST EDLGDKKEGE Y) as part of human SUMO-1 peptide (aa: 6-21) conjugated to diphtheria toxoid. This antigen shares 100% identity with SUMO-1 of rat.
Specificity This antiserum recognises human SUMO-1 and not ubiquitin.
Cross-Reactivity (Details) This antiserum is known to cross react with rat,human SUMO-1
Purification Whole antisera
Alternative Name SUMO1
Background FUNCTION: Ubiquitin-like protein which binds to a wide range of target proteins. Doesnot seem to be involved in protein degradation and may function as an antagonist ofubiquitin in the degradation process. Plays a role in a number of cellular processes suchas nuclear transport, DNA replication and repair, mitosis and signal transduction.Involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2.SUBUNIT: Covalently attached to a number of proteins such as PML, RANGAP1,HIPK2, SP100, p53, p73alpha, MDM2, JUN and DNMT3B. Also interacts with HIF1A,HIPK2, HIPK3, CHD3, PIAS1, EXOSC9, TDG, RAD51 and RAD52. SUBCELLULARLOCATION: Nucleus, nuclear membrane. Nucleus, nucleoplasm, nuclear speckle.Cytoplasm. SIMILARITY: Belongs to the ubiquitin family. SMT3 subfamily. SIMILARITY:Contains 1 ubiquitin-like domain. Alternate Names: anti-Small ubiquitin-related modifier 1 antibody, anti-Ubiquitin-like protein SMT3Cantibody, anti-SMT3 homolog 3 antibody, anti-Ubiquitin-homology domain protein PIC1antibody, anti-Ubiquitin-like protein UBL1 antibody, anti-GAP-modifying protein 1antibody, anti-GMP1 antibody, anti-Sentrin. GENE NAME: SUMO1 antibody,anti-SMT3C antibody, anti-SMT3H3 antibody, anti-UBL1 antibody, biosensis. Related Diseases: Alzheimer's/ Parkinson's
Gene Symbol: SUMO1
Gene ID 7341
Research Area Signaling, Proteases, DNA/RNA
Application Notes Immunohistochemistry-P and Western Blot Cell lysate from Hela and NIH-3T3 cell lysates may be used as a positive control, and for IHC, lung carcinoma may be used.
Recommended dilutions: Immunohistochemistry, Immunohistochemistry-Paraffin 1:2000 to 1:4000, Western Blot 1:4000 to 1:8000
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add diH20 to desired concentration.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Ohshima, Shimotohno: "Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4." in: The Journal of biological chemistry, Vol. 278, Issue 51, pp. 50833-42, 2003 (PubMed).

Bailey, OHare: "Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1." in: The Journal of biological chemistry, Vol. 279, Issue 1, pp. 692-703, 2003 (PubMed).

Pountney, Huang, Burns et al.: "SUMO-1 marks the nuclear inclusions in familial neuronal intranuclear inclusion disease." in: Experimental neurology, Vol. 184, Issue 1, pp. 436-46, 2003 (PubMed).

Ling, Sankpal, Robertson et al.: "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription." in: Nucleic acids research, Vol. 32, Issue 2, pp. 598-610, 2004 (PubMed).

Yang, Sharrocks: "SUMO promotes HDAC-mediated transcriptional repression." in: Molecular cell, Vol. 13, Issue 4, pp. 611-7, 2004 (PubMed).

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