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Leucine-Rich Repeat Kinase 2 (LRRK2) (AA 946-962) antibody

Details for Product No. ABIN271729
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Antigen
Epitope
AA 946-962
(45), (38), (36), (19), (12), (12), (8), (6), (6), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(173), (72), (69), (33), (13), (13), (2)
Host
Sheep
(99), (80), (6), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (10), (8), (6), (6), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(161), (68), (43), (42), (33), (20), (16), (12), (12), (6), (2), (1), (1)
Pubmed 10 references available
Quantity 0.1 mL
Shipping to United States (Change)
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN271729
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Immunogen A synthetic peptide (lkrkrkilssddslrss, aa 946-962) as part of human LRRK2 protein conjugated to the Blue Carrier Protein has been used as the immunogen.
Specificity LRRK2
Cross-Reactivity (Details) This antiserum has been successfully tested in human. Other species have not yet been tested.
Purification Whole antisera
Alternative Name PARK8 / LRRK2
Background This gene is a member of the leucine-rich repeat kinase family and encodes a proteinwith an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, aDFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40domain. The protein is present largely in the cytoplasm but also associates with themitochondrial outer membrane. Mutations in this gene have been associated withParkinson disease-8. Alternate Names: anti-LRRK-2 antibody, anti-LRRK 2 antibody, anti-PARK8 antibody, anti-ROCO2antibody, anti-Dardarin antibody, biosensis. Related Diseases: Alzheimer's/ Parkinson's
Gene Symbol: LRRK2
Gene ID 120892
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add diH20 to desired concentration.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Paisán-Ruíz, Jain, Evans et al.: "Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease." in: Neuron, Vol. 44, Issue 4, pp. 595-600, 2004 (PubMed).

Zimprich, Biskup, Leitner et al.: "Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology." in: Neuron, Vol. 44, Issue 4, pp. 601-7, 2004 (PubMed).

Nichols, Pankratz, Hernandez et al.: "Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease." in: Lancet, Vol. 365, Issue 9457, pp. 410-2, 2005 (PubMed).

Di Fonzo, Rohue, Ferreira et al.: "A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease." in: Lancet, Vol. 365, Issue 9457, pp. 412-5, 2005 (PubMed).

Gilks, Abou-Sleiman, Gandhi et al.: "A common LRRK2 mutation in idiopathic Parkinson's disease." in: Lancet, Vol. 365, Issue 9457, pp. 415-6, 2005 (PubMed).

Adams, van Netten, Schulzer et al.: "PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation." in: Brain : a journal of neurology, Vol. 128, Issue Pt 12, pp. 2777-85, 2005 (PubMed).

West, Moore, Biskup et al.: "Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 46, pp. 16842-7, 2005 (PubMed).

Gloeckner, Kinkl, Schumacher et al.: "The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity." in: Human molecular genetics, Vol. 15, Issue 2, pp. 223-32, 2006 (PubMed).

Galter, Westerlund, Carmine et al.: "LRRK2 expression linked to dopamine-innervated areas." in: Annals of neurology, Vol. 59, Issue 4, pp. 714-9, 2006 (PubMed).

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