Cyclin L1 antibody

Catalog No. ABIN271776

Product Details anti-Cyclin L1 Antibody

Target: Cyclin L1 (CCNL1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin L1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of Cyclin-L1 protein. (region surrounding Glu491)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen

Application Details

Application Notes: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Cyclin L1

Target: Cyclin L1 (CCNL1)

Alternative Name: Cyclin L1 (CCNL1 Products)

Synonyms: ANIA6A antibody, PRO1073 antibody, ania-6a antibody, 2610030E23Rik antibody, AU018493 antibody, Ccnl antibody, Ania-6a antibody, ccnl1 antibody, fd99b09 antibody, wu:fd99b09 antibody, zgc:55544 antibody, MCM2 antibody, cyclin-L1 antibody, MGC132032 antibody, bm-001 antibody, pro1073 antibody, MGC108436 antibody, Ccnl1 antibody, cyclin L1 antibody, cyclin L1b antibody, cyclin-L1 antibody, cyclin L1 L homeolog antibody, cyclin L1 S homeolog antibody, CCNL1 antibody, Ccnl1 antibody, ccnl1b antibody, LOC485730 antibody, ccnl1.L antibody, ccnl1 antibody, LOC100136245 antibody, ccnl1.S antibody

Background: Cell proliferation is controlled at specific stages of the cell cycle by distinct protein kinase complexes. These complexes consist of a catalytic subunit associating with a specific regulatory subunit to form the active kinase. The cyclins, which include cyclin A, B, C, D, E, F, G, H, I, K, L, T and their related proteins, including Dbf4, comprise the regulatory subunits of these kinase complexes. The controlled activation of the kinase complexes at various intervals of the cell cycle is regulated by the availability of the cyclins to the catalytic subunit. Unlike the catalytic subunit, which is expressed continually, the expression and stability of the regulatory subunit fluctuates depending on the stage of the cell cycle and, thereby, regulates the kinase activity. Cyclin L1 is a ubiquitously expressed nuclear protein that can be detected in higher levels in thymus. In neck and head squamous cell carcinomas, cyclin L1 can be overexpressed and is therefore often considered a proto-oncogene. It interacts with POLR2A, CDC2L and SFRS2. Cyclin L1 plays a role in the mRNA splicing process regulation.Synonyms: BM-001, CCNL1, Cyclin-L, Cyclin-L1

Molecular Weight: approx. 60 kDa

Gene ID: 57018

NCBI Accession: NP_064703

UniProt: Q9UK58