Peripherin antibody

Catalog No. ABIN271783

Product Details anti-Peripherin Antibody

Target: Peripherin (PRPH)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Peripherin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of Peripherin protein. (region surrounding Ser454)

Cross-Reactivity (Details): Species reactivity (tested):Human, Rat.

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1: 5000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Peripherin

Target: Peripherin (PRPH)

Alternative Name: Peripherin (PRPH Products)

Synonyms: NEF4 antibody, PRPH1 antibody, Prph1 antibody, Perf antibody, nef4 antibody, prph1 antibody, MGC69454 antibody, if3 antibody, plasticin antibody, zgc:111926 antibody, peripherin antibody, peripherin L homeolog antibody, PRPH antibody, Prph antibody, prph antibody, prph.L antibody

Background: Peripherin is a type III intermediate filament protein that is expressed in peripheral and some central nervous system (CNS) neurons. Peripherin activation is known to be induced by leukemia inhibitory factor (LIF). LIF activates Peripherin by inducing members of STAT transcription factor family to bind to a specific promoter element in the Peripherin gene. IL-6 is also known to induce Peripherin expression. Although it is not essential for neurite formation, peripherin is necessary for cellular intermediate filament network formation. Peripherin, unlike most intermediate filament proteins, has been reported to be modified by tyrosine phosphorylation.Synonyms: NEF4, PRPH, PRPH1

Molecular Weight: approx. 55 kDa

Gene ID: 5630

NCBI Accession: NP_006253

UniProt: P41219