Matrix Metallopeptidase 10 (Stromelysin 2) (MMP10) antibody

Details for Product No. ABIN272036, Supplier: Log in to see
Antigen
  • AV377895
  • MMP-10
  • SL-2
  • STMY2
  • MMP-3
  • MMP10
  • matrix metallopeptidase 10
  • matrix metallopeptidase 10 (stromelysin 2)
  • matrix metallopeptidase 3 (stromelysin 1, progelatinase)
  • matrix metalloproteinase 10
  • Mmp10
  • MMP10
  • MMP3
  • LOC100101603
Reactivity
Human, Mouse (Murine), Rat (Rattus)
162
26
15
Host
Rabbit
122
44
Clonality
Polyclonal
Conjugate
Un-conjugated
11
8
6
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
118
71
69
39
18
18
11
8
5
2
2
1
1
Options
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Specificity This antibody detects endogenous levels of MMP-10 protein. (region surrounding Ile387)
Cross-Reactivity (Details) Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
Purification Affinity Chromatography using epitope-specific immunogen
Alternative Name MMP-10 (MMP10 Antibody Abstract)
Background Proteins of the matrix metalloproteinase (MMP) family are zinc containing proteolytic enzymes involved in the breakdown of the extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling. They also play an important role in apoptosis, tumor cell growth, invasion, metastasis, as well as in angiogenesis and wound healing. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Most of the MMP's contain a common domain structure, which include a signal sequence, a propeptide, a catalytic domain and a hemopexin-like (Hpx) domain. MMP10 degrades proteoglycans, gelatins of type I, III, IV, and V, weakly collagens III, IV, and V. and fibronectin. It activates procollagenase. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.Synonyms: MMP10, Matrix metalloproteinase-10, SL-2, STMY2, Stromelysin-2, Transin-2
Molecular Weight approx. 54 kDa
Gene ID 4319
NCBI Accession NP_002416
UniProt P09238
Research Area Extracellular Matrix
Application Notes ELISA: 1: 20000approx. 1: 40000. IF: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Matrix Metallopeptidase 10 (Stromelysin 2) (MMP10) antibody (ABIN272036) anti-Matrix Metallopeptidase 10 (Stromelysin 2) (MMP10) antibody