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CLOCK antibody

CLOCK Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN272135
  • Target See all CLOCK Antibodies
    CLOCK (Clock Homolog (Mouse) (CLOCK))
    Reactivity
    • 48
    • 30
    • 24
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 44
    • 6
    • 1
    • 1
    Rabbit
    Clonality
    • 38
    • 14
    Polyclonal
    Conjugate
    • 34
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This CLOCK antibody is un-conjugated
    Application
    • 30
    • 18
    • 10
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody detects endogenous levels of Clock protein. (region surrounding Glu270)
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    Affinity Chromatography using epitope-specific immunogen.
    Top Product
    Discover our top product CLOCK Primary Antibody
  • Application Notes
    ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    CLOCK (Clock Homolog (Mouse) (CLOCK))
    Alternative Name
    CLOCK (CLOCK Products)
    Synonyms
    CG7391 antibody, CLK antibody, CLOCK antibody, Dmel\\CG7391 antibody, Jerk antibody, Jrk antibody, PAS1 antibody, bHLHe10 antibody, clk antibody, clock antibody, dCLK antibody, dCLK/JRK antibody, dCLOCK antibody, dClck antibody, dClk antibody, dClock antibody, dclk antibody, jrk antibody, Xclk antibody, XClock antibody, zCLOCK1 antibody, zfCLOCK1 antibody, 5330400M04Rik antibody, KAT13D antibody, bHLHe8 antibody, mKIAA0334 antibody, Clock antibody, clock circadian regulator antibody, clock homolog (mouse) antibody, clock circadian regulator a antibody, circadian locomotor output cycles kaput antibody, clock circadian regulator L homeolog antibody, Clk antibody, CLOCK antibody, clock antibody, clocka antibody, Clock antibody, clock.L antibody
    Background
    Biological timepieces called circadian clocks are responsible for the regulation of hormonal rhythms, sleep cycles and other behaviors. The superchiasmatic nucleus (SCN), which is located in the brain, was the first mammalian circadian clock to be discovered. Clock, a member of the basic-helix-loop-helix-PAS (bHLH-PAS) family of transcription factors, has also been identified as having circadian function. Mutations within the Clock gene have been shown to increase the length of the endogenous period and to cause a loss of rhythmicity of circadian oscillations. Clock contains a DNA-binding domain, a protein dimerization domain and a glutamine-rich C-terminal region, which indicates transactivation capabilities. It has been speculated that Clock may regulate circadian rhythmicity in combination with other proteins such as Per. Per is also a PAS-domain containing protein that exhibits circadian function. Highest expression of Clock is seen in the hypothalamus and the eye.Synonyms: BHLHE8, Circadian locomoter output cycles protein kaput, Class E basic helix-loop-helix protein 8, KIAA0334
    Molecular Weight
    approx. 95 kDa
    Gene ID
    9575
    NCBI Accession
    NP_004889
    UniProt
    O15516
    Pathways
    Regulation of Lipid Metabolism by PPARalpha, Photoperiodism
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