TPT1 antibody

Catalog No. ABIN272165

Product Details anti-TPT1 Antibody

Target: TPT1 (Tumor Protein, Translationally-Controlled 1 (TPT1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of HRF protein. (region surrounding Lys100)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Purity: > 95 % pure by SDS-PAGE

Application Details

Application Notes: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: DO NOT FREEZE!

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for TPT1

Target: TPT1 (Tumor Protein, Translationally-Controlled 1 (TPT1))

Alternative Name: TPT1 / TCTP (TPT1 Products)

Synonyms: HRF antibody, TCTP antibody, p02 antibody, Trt antibody, p21 antibody, p23 antibody, TPT1 antibody, TCT1 antibody, tctp antibody, fa28a02 antibody, id:ibd2078 antibody, wu:fa28a02 antibody, PCHK23 antibody, hrf antibody, MGC79720 antibody, Tpt1 antibody, translationally controlled tumor protein antibody, CG4800 antibody, Dmel\\CG4800 antibody, dTCTP antibody, Tctp antibody, tumor protein, translationally-controlled 1 antibody, tumor protein, translationally-controlled 1 L homeolog antibody, translationally-controlled tumor protein antibody, translationally controlled tumor protein antibody, translationally controlled tumor-like protein antibody, Translationally controlled tumor protein antibody, translationally-controlled tumor protein homolog antibody, P23 tumor protein-like antibody, TPT1 antibody, Tpt1 antibody, tpt1 antibody, tpt1.L antibody, LOC711798 antibody, TCTP antibody, LOC548038 antibody, Tctp antibody, LOC108708523 antibody, LOC109404863 antibody, LOC105389397 antibody, LOC102577554 antibody

Background: Histamine is an inflammatory mediator that is ubiquitously expressed and has a broad range of pharmacologic effects. Specifically, it plays a role in the central nervous, gastrointestinal, respiratory and immune systems. Histamine release is mediated by the stimulation of mast cells and basophils. Histamine-releasing factor (HRF) is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. HRF belongs to the translationally controlled tumor protein (TCTP) family and is detected as a protein of 21 kDa in mice and 23 kDa in human. It is expressed in several healthy and tumoral cells, including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas and lymphomas, and it is localized in the cytoplasm. HRF plays a pivotal role in allergic diseases, and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down Syndrome.Synonyms: Fortilin, HRF, Histamine-releasing factor, Translationally-controlled tumor protein

Molecular Weight: approx. 24 kDa

Gene ID: 7178

NCBI Accession: NP_003286

UniProt: P13693

Pathways: Response to Water Deprivation, Regulation of Cell Size, Negative Regulation of intrinsic apoptotic Signaling