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CDKL1 antibody

CDKL1 Reactivity: Human, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN272207
  • Target See all CDKL1 Antibodies
    CDKL1 (Cyclin-Dependent Kinase-Like 1 (CDC2-Related Kinase) (CDKL1))
    Reactivity
    • 43
    • 14
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 35
    • 8
    Rabbit
    Clonality
    • 36
    • 7
    Polyclonal
    Conjugate
    • 19
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This CDKL1 antibody is un-conjugated
    Application
    • 29
    • 21
    • 18
    • 6
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody detects endogenous levels of KKIALRE protein. (region surrounding asn301)
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, Rat.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
    Purity
    > 95 % pure by SDS-PAGE
    Top Product
    Discover our top product CDKL1 Primary Antibody
  • Application Notes
    ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    DO NOT FREEZE!
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    CDKL1 (Cyclin-Dependent Kinase-Like 1 (CDC2-Related Kinase) (CDKL1))
    Alternative Name
    CDKL1 (CDKL1 Products)
    Synonyms
    CDKL1 antibody, KKIALRE antibody, P42 antibody, 4933411O17Rik antibody, cyclin dependent kinase like 1 antibody, cyclin-dependent kinase-like 1 (CDC2-related kinase) antibody, CDKL1 antibody, cdkl1 antibody, Cdkl1 antibody
    Background
    The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated by the MAP kinases ERK 1 and ERK 2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group of proteins and is closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain and lung. KKIAMRE contains the conserved MAP kinase dual phosphorylation motif in the sequence Thr-Asp-Tyr and is activated by treatment of cells by EGF. However, unlike other MAP kinases, the EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif.Synonyms: Cyclin-dependent kinase-like 1, KKIALRE, Protein kinase p42 KKIALRE, Serine/threonine-protein kinase KKIALRE
    Molecular Weight
    approx. 42 kDa
    Gene ID
    8814
    NCBI Accession
    NP_004187
    UniProt
    Q00532
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