Cyclin-Dependent Kinase-Like 2 (CDC2-Related Kinase) (KKIAMRE) antibody

Details for Product No. ABIN272246, Supplier: Log in to see
Antigen
  • zgc:101002
  • CDKL2
  • DKFZp459L235
  • KKIAMRE
  • P56
  • kkiamre
  • 5330436L21Rik
  • AI505225
  • Kkm
  • cyclin-dependent kinase-like 1 (CDC2-related kinase)
  • cyclin-dependent kinase-like 2 (CDC2-related kinase)
  • cyclin-dependent kinase-like 1
  • cdkl1
  • CDKL2
  • CDKL1
  • BACOIKO006_03
  • cdkl2
  • Cdkl2
Reactivity
Human
48
4
3
3
2
2
2
2
2
1
1
1
1
Host
Rabbit
25
23
Clonality
Polyclonal
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
47
18
15
9
6
2
1
1
Options
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Specificity This antibody detects endogenous levels of KKIAMRE protein. (region surrounding Leu240)
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Purity > 95 % pure by SDS-PAGE
Alternative Name CDKL2 (KKIAMRE Antibody Abstract)
Background The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated by the MAP kinases ERK 1 and ERK 2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group of proteins and is closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain and lung. KKIAMRE contains the conserved MAP kinase dual phosphorylation motif in the sequence Thr-Asp-Tyr and is activated by treatment of cells by EGF. However, unlike other MAP kinases, the EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif.Synonyms: Cyclin-dependent kinase-like 2, KKIAMRE, Protein kinase p56 KKIAMRE, Serine/threonine-protein kinase KKIAMRE
Molecular Weight approx. 56 kDa
Gene ID 8999
NCBI Accession NP_003939
UniProt Q92772
Research Area Signaling
Application Notes ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1,0 mg/mL
Buffer Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
 image for anti-Cyclin-Dependent Kinase-Like 2 (CDC2-Related Kinase) (KKIAMRE) antibody (ABIN272246) anti-Cyclin-Dependent Kinase-Like 2 (CDC2-Related Kinase) (KKIAMRE) antibody
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