MERTK antibody (N-Term)

Catalog No. ABIN2746860

Product Details anti-MERTK Antibody

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MERTK antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP), Confocal Microscopy (CM)

Purification: Affinity Purified

Immunogen: Synthetic peptide corresponding to unique amino acid sequence on MerTK protein.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.75 μg/μL

References for anti-MERTK antibody (ABIN2746860)

Ginisty, Gély-Pernot, Abaamrane, Morel, Arnault, Coronas, Benzakour: "Evidence for a subventricular zone neural stem cell phagocytic activity stimulated by the vitamin K-dependent factor protein S." in: Stem cells (Dayton, Ohio), Vol. 33, Issue 2, pp. 515-25, (2015) (PubMed).

Farkas, Lew, Sousa, Bujakowska, Chatagnon, Bhattacharya, Pierce, Nandrot: "Mutations in pre-mRNA processing factors 3, 8, and 31 cause dysfunction of the retinal pigment epithelium." in: The American journal of pathology, Vol. 184, Issue 10, pp. 2641-52, (2014) (PubMed).

Fraineau, Monvoisin, Clarhaut, Talbot, Simonneau, Kanthou, Kanse, Philippe, Benzakour: "The vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent manner." in: Blood, Vol. 120, Issue 25, pp. 5073-83, (2013) (PubMed).

Choi, Park, Lee, Byun, Youn, Choi, Woo, Kang: "Upregulation of Mer receptor tyrosine kinase signaling attenuated lipopolysaccharide-induced lung inflammation." in: The Journal of pharmacology and experimental therapeutics, Vol. 344, Issue 2, pp. 447-58, (2013) (PubMed).

Qin, Rodrigues: "Roles of αvβ5, FAK and MerTK in oxidative stress inhibition of RPE cell phagocytosis." in: Experimental eye research, Vol. 94, Issue 1, pp. 63-70, (2012) (PubMed).

Lee, Han, Byun, Park, Park, Chong, Cho, Kang: "Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-κB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury." in: Journal of leukocyte biology, Vol. 91, Issue 6, pp. 921-32, (2012) (PubMed).

Caberoy, Zhou, Li: "Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis." in: The EMBO journal, Vol. 29, Issue 23, pp. 3898-910, (2011) (PubMed).

Tibrewal, Wu, Dmello, Akakura, George, Varnum, Birge: "Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activation." in: The Journal of biological chemistry, Vol. 283, Issue 6, pp. 3618-27, (2008) (PubMed).

Wu, Singh, Georgescu, Birge: "A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells." in: Journal of cell science, Vol. 118, Issue Pt 3, pp. 539-53, (2005) (PubMed).

Target Details for MERTK

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Alternative Name: MERTK (MERTK Products)

Synonyms: MER antibody, RP38 antibody, c-mer antibody, Eyk antibody, Mer antibody, Nyk antibody, nmf12 antibody, rdy antibody, C-EYK antibody, MERTK antibody, DKFZp469D2215 antibody, si:ch1073-268l12.2 antibody, MER proto-oncogene, tyrosine kinase antibody, c-mer proto-oncogene tyrosine kinase antibody, c-mer proto-oncogene tyrosine kinase a antibody, MERTK antibody, Mertk antibody, mertka antibody

UniProt: Q12866

Pathways: RTK Signaling