Integrin Alpha2b antibody

Catalog No. ABIN2749191

Product Details anti-Integrin Alpha2b Antibody

Target: Integrin Alpha2b (CD41)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Integrin Alpha2b antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func)

Specificity: The rat monoclonal antibody MWReg30 recognizes an extracellular epitope of CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain, 120 kDa) and GPIIb beta (light chain, 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.

Cross-Reactivity (Details): Mouse

Purification: Purified by protein-G affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Endotoxin Level: Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Immunogen: Murine platelets

Clone: MWReg30

Isotype: IgG1 kappa

Application Details

Application Notes: Functional application: Platelet depletion.
Flow cytometry: Recommended dilution: 1-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Preservative: Azide free

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

References for anti-Integrin Alpha2b antibody (ABIN2749191)

Ramsey, Zhang, Brown, Steensma, Lin, Wu: "Stress-induced hematopoietic failure in the absence of immediate early response gene X-1 (IEX-1, IER3)." in: Haematologica, Vol. 99, Issue 2, pp. 282-91, (2014) (PubMed).

Brancaleone, Gobbetti, Cenac, le Faouder, Colom, Flower, Vergnolle, Nourshargh, Perretti: "A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation." in: Blood, Vol. 122, Issue 4, pp. 608-17, (2013) (PubMed).

Boisset, Clapes, Van Der Linden, Dzierzak, Robin: "Integrin αIIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta." in: Biology open, Vol. 2, Issue 5, pp. 525-32, (2013) (PubMed).

Sullivan, Wang, Tawfik, Luyendyk: "Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 115, Issue 1, pp. 286-94, (2010) (PubMed).

Target Details for Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Alternative Name: CD41 (CD41 Products)

Synonyms: AI172977 antibody, CD41 antibody, CD41B antibody, GpIIb antibody, alphaIIb antibody, BDPLT16 antibody, BDPLT2 antibody, GP2B antibody, GPIIb antibody, GT antibody, GTA antibody, HPA3 antibody, integrin alpha 2b antibody, integrin subunit alpha 2b antibody, Itga2b antibody, ITGA2B antibody

Background: Integrin subunit alpha 2b,CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.,Platelet GPIIb, Integrin alpha-IIb, GPalpha IIb, GPIIb

Gene ID: 16399

UniProt: Q9QUM0

Pathways: Integrin Complex