ICMT antibody (Middle Region)

Catalog No. ABIN2773889

Product Details anti-ICMT Antibody

Target: ICMT (Isoprenylcysteine Carboxyl Methyltransferase (ICMT))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Guinea Pig, Cow, Dog, Horse, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ICMT antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GSNFNHVVQN EKSDTHTLVT SGVYAWFRHP SYVGWFYWSI GTQVMLCNPI

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 79%

Characteristics: This is a rabbit polyclonal antibody against ICMT. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ICMT

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 284 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-ICMT antibody (ABIN2773889)

Nuthalapaty, Lu, Ramin, Nuthalapaty, Ramin, Ramsey: "Is there a preferred gestational age threshold of viability?: a survey of maternal-fetal medicine providers." in: The journal of maternal-fetal & neonatal medicine, Vol. 20, Issue 4, pp. 293-7, (2007) (PubMed).

Target Details for ICMT

Target: ICMT (Isoprenylcysteine Carboxyl Methyltransferase (ICMT))

Alternative Name: ICMT (ICMT Products)

Synonyms: HSTE14 antibody, MST098 antibody, MSTP098 antibody, PCCMT antibody, PCMT antibody, PPMT antibody, 1700008E11Rik antibody, C80758 antibody, Gm13095 antibody, OTTMUSG00000010406 antibody, STE14 antibody, pcCMT antibody, fcmt antibody, im:6895697 antibody, zgc:110258 antibody, isoprenylcysteine carboxyl methyltransferase antibody, cobalt-zinc-cadmium resistance protein antibody, Isoprenylcysteine carboxyl methyltransferase antibody, isoprenylcysteine carboxylmethyltransferase family protein antibody, isoprenylcysteine carboxyl methyltransferase S homeolog antibody, ICMT antibody, Icmt antibody, icmt antibody, Bcen_5417 antibody, Acid_0983 antibody, Bcenmc03_4825 antibody, RPIC_RS08670 antibody, Mesil_1887 antibody, Slip_1333 antibody, Deba_2487 antibody, Bresu_2161 antibody, MPET_RS04760 antibody, MPET_RS08305 antibody, Saut_0066 antibody, Intca_3523 antibody, Deima_2891 antibody, Despr_1203 antibody, Deipr_0831 antibody, Theth_0229 antibody, icmt.S antibody

Background: ICMT is the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.
Alias Symbols: HSTE14, MGC39955, MST098, MSTP098, PCCMT, PCMT, PPMT
Protein Interaction Partner: ELAVL1, UBC, RAC2, RAC1, HRAS, RHOA,
Protein Size: 284

Molecular Weight: 32 kDa

Gene ID: 23463

NCBI Accession: NM_012405, NP_036537

UniProt: O60725