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CTDSP2 antibody (Middle Region)

CTDSP2 Reactivity: Human, Rat, Mouse, Horse, Cow, Rabbit, Guinea Pig, Dog, Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2774003
  • Target See all CTDSP2 Antibodies
    CTDSP2 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2 (CTDSP2))
    Binding Specificity
    • 16
    • 11
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 48
    • 19
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Horse, Cow, Rabbit, Guinea Pig, Dog, Pig
    Host
    • 43
    • 5
    Rabbit
    Clonality
    • 44
    • 4
    Polyclonal
    Conjugate
    • 23
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CTDSP2 antibody is un-conjugated
    Application
    • 31
    • 22
    • 14
    • 13
    • 13
    • 6
    • 6
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    ASYIFHPENA VPVQSWFDDM ADTELLNLIP IFEELSGAED VYTSLGQLRA
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 91%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against CTDSP2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human CTDSP2
    Top Product
    Discover our top product CTDSP2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 271 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    CTDSP2 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2 (CTDSP2))
    Alternative Name
    CTDSP2 (CTDSP2 Products)
    Synonyms
    fb16c04 antibody, wu:fb16c04 antibody, zgc:77714 antibody, MGC68415 antibody, CTDSP2 antibody, OS4 antibody, PSR2 antibody, SCP2 antibody, AI586070 antibody, D10Ertd73e antibody, OS-4 antibody, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 antibody, CTD small phosphatase 2 L homeolog antibody, CTD small phosphatase 2 antibody, ctdsp2 antibody, ctdsp2.L antibody, CTDSP2 antibody, Ctdsp2 antibody
    Background
    CTDSP2 preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A.CTDSP2 negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. CTDSP2 is recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.CTDSP2 may contribute to the development of sarcomas.
    Alias Symbols: OS4, PSR2, SCP2
    Protein Interaction Partner: CDCA3, UBC, AR, SNAI1, POLR2A,
    Protein Size: 271
    Molecular Weight
    31 kDa
    Gene ID
    10106
    NCBI Accession
    NM_005730, NP_005721
    UniProt
    O14595
    Pathways
    ER-Nucleus Signaling
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