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CAMKK2 antibody (N-Term)

CAMKK2 Reactivity: Human, Mouse, Rat, Pig, Guinea Pig, Cow, Rabbit, Dog, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2774040
  • Target See all CAMKK2 Antibodies
    CAMKK2 (Calcium/calmodulin-Dependent Protein Kinase Kinase 2, beta (CAMKK2))
    Binding Specificity
    • 17
    • 16
    • 9
    • 8
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 62
    • 40
    • 23
    • 17
    • 17
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Pig, Guinea Pig, Cow, Rabbit, Dog, Zebrafish (Danio rerio)
    Host
    • 69
    • 7
    Rabbit
    Clonality
    • 71
    • 5
    Polyclonal
    Conjugate
    • 37
    • 7
    • 6
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CAMKK2 antibody is un-conjugated
    Application
    • 71
    • 35
    • 21
    • 14
    • 10
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    GGLAAGGSLD MNGRCICPSL PYSPVSSPQS SPRLPRRPTV ESHHVSITGM
    Predicted Reactivity
    Cow: 93%, Dog: 93%, Guinea Pig: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 93%, Rat: 86%, Zebrafish: 79%
    Characteristics
    This is a rabbit polyclonal antibody against CAMKK2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human CAMKK2
    Top Product
    Discover our top product CAMKK2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 498 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    CAMKK2 (Calcium/calmodulin-Dependent Protein Kinase Kinase 2, beta (CAMKK2))
    Alternative Name
    CAMKK2 (CAMKK2 Products)
    Synonyms
    CAMKK antibody, CAMKKB antibody, 6330570N16Rik antibody, AW061083 antibody, mKIAA0787 antibody, camk2b antibody, fj90d04 antibody, wu:fj90d04 antibody, si:dkey-174n20.2 antibody, CAMKK2 antibody, calcium/calmodulin dependent protein kinase kinase 2 antibody, calcium/calmodulin-dependent protein kinase kinase 2, beta antibody, calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 antibody, calcium/calmodulin dependent protein kinase II beta antibody, calcium/calmodulin-dependent protein kinase kinase 2 antibody, CAMKK2 antibody, Camkk2 antibody, camk2b1 antibody, CAMK2B antibody, camkk2 antibody
    Background
    CAMKK2 is a calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. CAMKK2 seems to be involved in hippocampal activation of CREB1.The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Seven transcript variants encoding six distinct isoforms have been identified for this gene. Additional splice variants have been described but their full-length nature has not been determined. The identified isoforms exhibit a distinct ability to undergo autophosphorylation and to phosphorylate the downstream kinases.
    Alias Symbols: CAMKK, CAMKKB, KIAA0787, MGC15254
    Protein Interaction Partner: HSP90AA1, APP, UBC, NEDD4, CEP63, ESYT2, FANCI, OBSL1, ATG4B, XPOT, GCN1L1, IQGAP2, SMC3, SLC25A11, SMC1A, PRKDC, PRKAG1, PRKAA2, IRAK1, FLNC, FLNA, MAPK14, CALM1, CAMK4, CAMK1, PRKACA, SGK1,
    Protein Size: 498
    Molecular Weight
    55 kDa
    Gene ID
    10645
    NCBI Accession
    NM_153500, NP_705720
    UniProt
    Q96RR4
    Pathways
    AMPK Signaling
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