RNF216 antibody (N-Term)

Catalog No. ABIN2774202

Product Details anti-RNF216 Antibody

Target: RNF216 (Ring Finger Protein 216 (RNF216))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Horse, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF216 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IVNPRLEQKV IILGENGLLF PESEPLEVQN QSSEDSETEL LSNPGEPAAS

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against Rnf216. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of MOUSE Rnf216

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RNF216

Target: RNF216 (Ring Finger Protein 216 (RNF216))

Alternative Name: Rnf216 (RNF216 Products)

Synonyms: RGD1565135 antibody, TRIAD3 antibody, RNF216 antibody, zin antibody, u7i1 antibody, triad3 antibody, ubce7ip1 antibody, MGC147026 antibody, 2810055g22rik antibody, 2810055G22Rik antibody, AI647468 antibody, AU019462 antibody, C86502 antibody, F830018F18Rik antibody, UIP83 antibody, Ubce7ip1 antibody, CAHH antibody, U7I1 antibody, UBCE7IP1 antibody, ZIN antibody, ring finger protein 216 antibody, Rnf216 antibody, RNF216 antibody, rnf216 antibody

Background: Rnf216 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. It promotes degradation of TRAF3, TLR4 and TLR9. It contributes to the regulation of antiviral responses. It down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production and promotes TNF and RIP mediated apoptosis.
Protein Interaction Partner: Ube2l3,
Protein Size: 853

Molecular Weight: 93 kDa

Gene ID: 108086

UniProt: P58283