KIR2DL5A antibody (C-Term)

Catalog No. ABIN2774436

Product Details anti-KIR2DL5A Antibody

Target: KIR2DL5A (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5A (KIR2DL5A))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIR2DL5A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: QLDHCVFTQT KITSPSQRPK TPPTDTTMYM ELPNAKPRSL SPAHKHHSQA

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against KIR2DL5A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human KIR2DL5A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 375 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KIR2DL5A

Target: KIR2DL5A (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5A (KIR2DL5A))

Alternative Name: KIR2DL5A (KIR2DL5A Products)

Synonyms: CD158F antibody, KIR2DL5 antibody, KIR2DL5.1 antibody, KIR2DL5.3 antibody, KIR2DL5B antibody, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A antibody, KIR2DL5A antibody

Background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.
Alias Symbols: CD158F, KIR2DL5, KIR2DL5.1, KIR2DL5.3
Protein Interaction Partner: PTPN6, PTPN11,
Protein Size: 375

Molecular Weight: 41 kDa

Gene ID: 57292

NCBI Accession: NM_020535, NP_065396

UniProt: Q8N109