LGMN antibody (Middle Region)

Catalog No. ABIN2774455

Product Details anti-LGMN Antibody

Target: LGMN (Legumain (LGMN))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Guinea Pig, Horse, Zebrafish (Danio rerio), Sheep, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LGMN antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ESSYACYYDE KRSTYLGDWY SVNWMEDSDV EDLTKETLHK QYHLVKSHTN

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 86%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against LGMN. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human LGMN

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 433 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for LGMN

Target: LGMN (Legumain (LGMN))

Alternative Name: LGMN (LGMN Products)

Synonyms: AEP antibody, LGMN1 antibody, PRSC1 antibody, AI746452 antibody, AU022324 antibody, Prsc1 antibody, MGC64351 antibody, cb173 antibody, cb460 antibody, sb:cb173 antibody, zgc:76953 antibody, wu:fa98g05 antibody, wu:fj92g08 antibody, lgmn antibody, MGC88980 antibody, DELTA VACUOLAR PROCESSING ENZYME antibody, DELTAVPE antibody, delta vacuolar processing enzyme antibody, legumain antibody, legumain L homeolog antibody, delta vacuolar processing enzyme antibody, Legumain antibody, LGMN antibody, Lgmn antibody, lgmn.L antibody, lgmn antibody, DELTA-VPE antibody, MBOO_RS07785 antibody, Odosp_3582 antibody, LOC569153 antibody

Background: This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.
Alias Symbols: AEP, LGMN1, PRSC1
Protein Interaction Partner: USP17L2, TRAF6, USP17L9P, SUMO1, UBC, NEDD8, LAMC3, ACIN1, IGF2BP3, HNRNPR, FBXO6, ISG15, LGMN,
Protein Size: 433

Molecular Weight: 48 kDa

Gene ID: 5641

NCBI Accession: NM_005606, NP_005597

UniProt: Q99538

Pathways: Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades