NR2F2 antibody (N-Term)

Catalog No. ABIN2774661

Product Details anti-NR2F2 Antibody

Target: NR2F2 (Nuclear Receptor Subfamily 2, Group F, Member 2 (NR2F2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Dog, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR2F2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AMVVSTWRDP QDEVPGSQGS QASQAPPVPG PPPGAPHTPQ TPGQGGPAST

Cross-Reactivity: Cow (Bovine), Dog (Canine), Chicken, Human, Mouse (Murine), Rat (Rattus)

Predicted Reactivity: Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%

Characteristics: This is a rabbit polyclonal antibody against NR2F2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NR2F2

Application Details

Application Notes: WB Suggested Anti-NR2F2 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:62500
Positive Control: Human brain.
Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 414 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NR2F2

Target: NR2F2 (Nuclear Receptor Subfamily 2, Group F, Member 2 (NR2F2))

Alternative Name: NR2F2 (NR2F2 Products)

Synonyms: nr2f2 antibody, MGC52954 antibody, ARP1 antibody, COUPTFB antibody, COUPTFII antibody, NF-E3 antibody, NR2F1 antibody, SVP40 antibody, TFCOUP2 antibody, 2700033K02Rik antibody, 9430015G03Rik antibody, ARP-1 antibody, Aporp1 antibody, COUP-TF2 antibody, COUP-TFII antibody, EAR3 antibody, Tcfcoup2 antibody, Tfcoup2 antibody, fc94g08 antibody, svp40 antibody, svp[40] antibody, wu:fc94g08 antibody, nuclear receptor subfamily 2 group F member 2 L homeolog antibody, Nr2f2 protein antibody, nuclear receptor subfamily 2 group F member 2 antibody, nuclear receptor subfamily 2, group F, member 2 antibody, nr2f2.L antibody, nr2f2 antibody, NR2F2 antibody, Nr2f2 antibody

Background: NR2F2, an orphan member of the nuclear hormone receptor superfamily, acts as a transcriptional repressor by antagonizing the functions of other nuclear hormone receptors and by actively silencing transcription. However, in certain contexts, NR2F2 stimulates transcription directly. NR2F2, MyoD and p300 interact in a competitive manner, and that increasing amounts of NR2F2 have the ability to reduce the interaction between myoD and p300 invitro. NR2F2 post-transcriptionally regulates myoD activity/function, and that crosstalk between orphan nuclear receptors and the myogenic bHLH proteins has functional consequences for differentiation.
Alias Symbols: ARP1, COUP-TFII, COUPTFB, MGC117452, SVP40, TFCOUP2, NF-E3, NR2F1, COUPTFII
Protein Interaction Partner: NSD1, BCL11A, NR2F2, BIK, SETD7, FAM46A, HIPK3, UBC, TFAP4, Cebpb, SMARCAD1, NR2F6, POU5F1, NR3C1, PHB2, TRIP4, PIAS1, BCL11B, TRIM24, EP300, SQSTM1, HDAC1, NCOR2, MYOD1, LCK,
Protein Size: 414

Molecular Weight: 45 kDa

Gene ID: 7026

NCBI Accession: NM_021005, NP_066285

UniProt: P24468

Pathways: Steroid Hormone Mediated Signaling Pathway