Annexin A3 antibody (N-Term)

Catalog No. ABIN2774839

Product Details anti-Annexin A3 Antibody

Target: Annexin A3 (ANXA3)

Binding Specificity: N-Term

Reactivity: Human, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Annexin A3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: MASIWVGHRG TVRDYPDFSP SVDAEAIQKA IRGIGTDEKM LISILTERSN

Predicted Reactivity: Dog: 79%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 79%, Rabbit: 93%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against ANXA3. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ANXA3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 323 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Annexin A3 antibody (ABIN2774839)

Meyer-Schwesinger, Dehde, Klug, Becker, Mathey, Arefi, Balabanov, Venz, Endlich, Pekna, Gessner, Thaiss, Meyer: "Nephrotic syndrome and subepithelial deposits in a mouse model of immune-mediated anti-podocyte glomerulonephritis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 6, pp. 3218-29, (2011) (PubMed).

Bianchi, Bombelli, Raimondo, Torsello, Angeloni, Ferrero, Di Stefano, Chinello, Cifola, Invernizzi, Brambilla, Magni, Pitto, Zanetti, Mocarelli, Perego: "Primary cell cultures from human renal cortex and renal-cell carcinoma evidence a differential expression of two spliced isoforms of Annexin A3." in: The American journal of pathology, Vol. 176, Issue 4, pp. 1660-70, (2010) (PubMed).

Schordan, Schordan, Endlich, Lindenmeyer, Meyer-Schwesinger, Meyer, Giebel, Cohen, Endlich, Maurer: "Alterations of the podocyte proteome in response to high glucose concentrations." in: Proteomics, Vol. 9, Issue 19, pp. 4519-28, (2009) (PubMed).

Seliger, Dressler, Wang, Kellner, Recktenwald, Lottspeich, Marincola, Baumgärtner, Atkins, Lichtenfels: "Combined analysis of transcriptome and proteome data as a tool for the identification of candidate biomarkers in renal cell carcinoma." in: Proteomics, Vol. 9, Issue 6, pp. 1567-81, (2009) (PubMed).

Target Details for Annexin A3

Target: Annexin A3 (ANXA3)

Alternative Name: ANXA3 (ANXA3 Products)

Synonyms: MGC80326 antibody, anxa3 antibody, zgc:101718 antibody, ANXA3 antibody, ANX3 antibody, Anx3 antibody, LC3 antibody, LRRGT00047 antibody, annexin A3 L homeolog antibody, annexin A3a antibody, annexin A3 antibody, Annexin A3 antibody, anxa3.L antibody, anxa3a antibody, ANXA3 antibody, anxa3 antibody, Anxa3 antibody

Background: The ANXA3 gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.
Alias Symbols: ANX3
Protein Interaction Partner: UBC, ATF2, SNAP23, STXBP2, STX4, ANXA11, ANXA4, ISG15, EMG1, IGSF21, UBR1, UNC119, TP53, REG3A,
Protein Size: 323

Molecular Weight: 36 kDa

Gene ID: 306

NCBI Accession: NM_005139, NP_005130

UniProt: P12429