THO Complex 4 antibody (N-Term)

Catalog No. ABIN2774915

Product Details anti-THO Complex 4 Antibody

Target: THO Complex 4 (THOC4)

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This THO Complex 4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: GGGPIRNRPA IARGAAGGGG RNRPAPYSRP KQLPDKWQHD LFDSGFGGGA

Predicted Reactivity: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against THOC4. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human THOC4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 257 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-THO Complex 4 antibody (ABIN2774915)

Ding, Enriquez-Algeciras, Dave, Perez-Pinzon, Bhattacharya: "The role of deimination in ATP5b mRNA transport in a transgenic mouse model of multiple sclerosis." in: EMBO reports, Vol. 13, Issue 3, pp. 230-6, (2012) (PubMed).

Strässer, Masuda, Mason, Pfannstiel, Oppizzi, Rodriguez-Navarro, Rondón, Aguilera, Struhl, Reed, Hurt: "TREX is a conserved complex coupling transcription with messenger RNA export." in: Nature, Vol. 417, Issue 6886, pp. 304-8, (2002) (PubMed).

Target Details for THO Complex 4

Target: THO Complex 4 (THOC4)

Alternative Name: THOC4 (THOC4 Products)

Synonyms: THOC4 antibody, Aly antibody, ALY antibody, ALY/REF antibody, BEF antibody, REF antibody, tho4 antibody, thoc4 antibody, zgc:171753 antibody, Tho4-A antibody, alyref-a antibody, thoc4-a antibody, REF1 antibody, Refbp1 antibody, Thoc4 antibody, Tho4 antibody, Aly/REF export factor antibody, THO complex 4 antibody, Aly/REF export factor L homeolog antibody, ALYREF antibody, Thoc4 antibody, alyref antibody, alyref.L antibody, Alyref antibody

Background: THOC4 is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins.The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins.
Alias Symbols: ALY, BEF, REF, THOC4, ALY/REF
Protein Interaction Partner: TP53, AKT1, NEDD1, THOC3, NCBP1, THOC2, CEP250, THOC5, DDX39B, STAU1, UBC, MDM2, SUZ12, EED, RNF2, FBXO6, CD81, ICAM1, IGSF8, PAN2, VCAM1, ITGA4, IL7R, FN1, CBX8, EIF4A3, MAGOH, PAXIP1, TRIP12, TRIP13, UBE2I, SF3B4, TLE3, YBX1, HNRNPM, ERCC4, ATP6V1E1, UB
Protein Size: 257

Molecular Weight: 28 kDa

Gene ID: 10189

NCBI Accession: NM_005782, NP_005773

UniProt: Q86V81