HELLS antibody (Middle Region)

Catalog No. ABIN2775238

Product Details anti-HELLS Antibody

Target: HELLS (Helicase, Lymphoid-Specific (HELLS))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Horse, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HELLS antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: QSGLNLSKNF LDPKELMELL KSRDYEREIK GSREKVISDK DLELLLDRSD

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against HELLS. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HELLS

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 838 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HELLS

Target: HELLS (Helicase, Lymphoid-Specific (HELLS))

Alternative Name: HELLS (HELLS Products)

Synonyms: HELLS antibody, cb65 antibody, pasg antibody, sb:cb65 antibody, sb:cb749 antibody, im:6911667 antibody, AI323785 antibody, E130115I21Rik antibody, LSH antibody, Lysh antibody, PASG antibody, YFK8 antibody, Tbc1d12 antibody, SMARCA6 antibody, lsh antibody, nbla10143 antibody, smarca6 antibody, helicase, lymphoid-specific antibody, helicase, lymphoid specific antibody, helicase, lymphoid specific L homeolog antibody, HELLS antibody, hells antibody, Hells antibody, hells.L antibody

Background: HELLS is a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis.This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Alias Symbols: FLJ10339, LSH, Nbla10143, PASG, SMARCA6
Protein Interaction Partner: UBC, VCP, APP, SUMO2, E2F3, SMARCAD1, MYC, HDAC2, HDAC1, DNMT3B, DNMT1, RPAP2, RPAP3,
Protein Size: 838

Molecular Weight: 92 kDa

Gene ID: 3070

NCBI Accession: NM_018063, NP_060533

UniProt: Q9NRZ9

Pathways: Chromatin Binding