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IDH3A antibody (N-Term)

IDH3A Reactivity: Human, Rat, Mouse, Cow, Dog, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio) WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2775312
  • Target See all IDH3A Antibodies
    IDH3A (Isocitrate Dehydrogenase 3 (NAD+) alpha (IDH3A))
    Binding Specificity
    • 15
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 43
    • 30
    • 16
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Cow, Dog, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio)
    Host
    • 39
    • 3
    • 1
    Rabbit
    Clonality
    • 41
    • 2
    Polyclonal
    Conjugate
    • 18
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This IDH3A antibody is un-conjugated
    Application
    • 32
    • 13
    • 13
    • 11
    • 9
    • 7
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    MKIFDAAKAP IQWEERNVTA IQGPGGKWMI PSEAKESMDK NKMGLKGPLK
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%
    Characteristics
    This is a rabbit polyclonal antibody against IDH3A. It was validated on Western Blot and immunohistochemistry.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human IDH3A
    Top Product
    Discover our top product IDH3A Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 366 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Lin, Cheng, Tsai, Tsai, Hu, Chang, Yeh, Chen, Liao, Chang: "Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy." in: Scientific reports, Vol. 2, pp. 785, (2012) (PubMed).

  • Target
    IDH3A (Isocitrate Dehydrogenase 3 (NAD+) alpha (IDH3A))
    Alternative Name
    IDH3A (IDH3A Products)
    Synonyms
    idh3a antibody, MGC76128 antibody, IDH3A antibody, zgc:56380 antibody, zgc:85631 antibody, BG1 antibody, 1110003P10Rik antibody, 1500012E04Rik antibody, AA407078 antibody, AI316514 antibody, isocitrate dehydrogenase 3 (NAD+) alpha antibody, isocitrate dehydrogenase 3 (NAD(+)) alpha antibody, isocitrate dehydrogenase 3 (NAD+) alpha S homeolog antibody, idh3a antibody, IDH3A antibody, idh3a.S antibody, Idh3a antibody
    Background
    Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. IDH3A is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase.Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase.
    Protein Interaction Partner: HUWE1, SUMO2, STAU1, UBC, MDM2, ADRB2, gag-pol, RAB4A, MBNL1, S100A16, SUCLA2, UQCRFS1P1, SUMO4, EBNA-LP, MYC, TERF2, TERF1, PSMD4, DDA1, DMWD, IDH3B, IDH3G,
    Protein Size: 366
    Molecular Weight
    40 kDa
    Gene ID
    3419
    NCBI Accession
    NM_005530, NP_005521
    UniProt
    P50213
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