NNMT antibody (N-Term)

Catalog No. ABIN2775335

Product Details anti-NNMT Antibody

Target: NNMT (Nicotinamide N-Methyltransferase (NNMT))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NNMT antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MESGFTSKDT YLSHFNPRDY LEKYYKFGSR HSAESQILKH LLKNLFKIFC

Predicted Reactivity: Dog: 93%, Human: 100%, Mouse: 100%, Pig: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against NNMT. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NNMT

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Antigen size: 264 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-NNMT antibody (ABIN2775335)

Ulanovskaya, Zuhl, Cravatt: "NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink." in: Nature chemical biology, Vol. 9, Issue 5, pp. 300-6, (2013) (PubMed).

Target Details for NNMT

Target: NNMT (Nicotinamide N-Methyltransferase (NNMT))

Alternative Name: NNMT (NNMT Products)

Synonyms: MGC64498 antibody, Afu1g17750 antibody, AO090026000620 antibody, nnmt antibody, nicotinamide N-methyltransferase S homeolog antibody, nicotinamide N-methyltransferase antibody, nicotinamide n-methyltransferase antibody, Nicotinamide N-methyltransferase antibody, nnmt.S antibody, CNG02680 antibody, AFUA_1G17750 antibody, AOR_1_1132194 antibody, AOR_1_1124014 antibody, CC1G_02598 antibody, VDBG_08111 antibody, TERG_00572 antibody, Tsp_04293 antibody, nnmt antibody, NNMT antibody, Nnmt antibody

Background: N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor.N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor.
Protein Interaction Partner: UBC, BMF, ATF6, APP,
Protein Size: 264

Molecular Weight: 29 kDa

Gene ID: 4837

NCBI Accession: NM_006169, NP_006160

UniProt: P40261