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PPP2R3B antibody (C-Term)

PPP2R3B Reactivity: Human, Mouse, Dog, Cow, Rat, Zebrafish (Danio rerio), Guinea Pig, Horse, Rabbit WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2775379
  • Target See all PPP2R3B Antibodies
    PPP2R3B (Protein Phosphatase 2A 48 KDa Regulatory Subunit (PPP2R3B))
    Binding Specificity
    • 10
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    Human, Mouse, Dog, Cow, Rat, Zebrafish (Danio rerio), Guinea Pig, Horse, Rabbit
    Host
    • 29
    • 6
    Rabbit
    Clonality
    • 32
    • 3
    Polyclonal
    Conjugate
    • 25
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PPP2R3B antibody is un-conjugated
    Application
    • 22
    • 14
    • 5
    • 4
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    TFFNIEKYLD HEQKEQISLL RDGDSGGPEL SDWEKYAAEE YDILVAEETA
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 77%, Horse: 77%, Human: 100%, Mouse: 77%, Rabbit: 77%, Rat: 82%, Zebrafish: 85%
    Characteristics
    This is a rabbit polyclonal antibody against PPP2R3B. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human PPP2R3B
    Top Product
    Discover our top product PPP2R3B Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 575 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • van Kempen, Redpath, Elchebly, Klein, Papadakis, Wilmott, Scolyer, Edqvist, Pontén, Schadendorf, van Rijk, Michiels, Dumay, Helbling-Leclerc, Dessen, Wouters, Stass, Greenwood, Ghanem, van den Oord et al.: "The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene. ..." in: Science translational medicine, Vol. 8, Issue 369, pp. 369ra177, (2016) (PubMed).

  • Target
    PPP2R3B (Protein Phosphatase 2A 48 KDa Regulatory Subunit (PPP2R3B))
    Alternative Name
    PPP2R3B (PPP2R3B Products)
    Synonyms
    NYREN8 antibody, PPP2R3L antibody, PPP2R3LY antibody, PR48 antibody, im:6895423 antibody, si:ch211-269e2.2 antibody, protein phosphatase 2 regulatory subunit B''beta antibody, serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta antibody, protein phosphatase 2, regulatory subunit B'', beta antibody, protein phosphatase 2 regulatory subunit B', beta L homeolog antibody, PPP2R3B antibody, LOC607103 antibody, ppp2r3b antibody, ppp2r3b.L antibody, Ppp2r3b antibody
    Background
    Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. PPP2R3B belongs to the B'' family. The B'' family has been further divided into subfamilies. PPP2R3B belongs to the beta subfamily of regulatory subunit B''.Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.
    Alias Symbols: NY-REN-8, PPP2R3L, PPP2R3LY, PR48, NYREN8
    Protein Interaction Partner: DUSP12, UBC, PPP2R1A, CDC6, PPP2R1B, PPP2CA,
    Protein Size: 575
    Molecular Weight
    65 kDa
    Gene ID
    28227
    NCBI Accession
    NM_013239, NP_037371
    UniProt
    Q9Y5P8
    Pathways
    PI3K-Akt Signaling, Mitotic G1-G1/S Phases
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