EPB41 antibody (N-Term)

Catalog No. ABIN2775561

Product Details anti-EPB41 Antibody

Target: EPB41 (Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Horse, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPB41 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SESRGLSRLF SSFLKRPKSQ VSEEEGKEVE SDKEKGEGGQ KEIEFGTSLD

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against EPB41. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human EPB41

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 775 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for EPB41

Target: EPB41 (Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41))

Alternative Name: EPB41 (EPB41 Products)

Synonyms: P4.1R antibody, epb41 antibody, wu:fb70c02 antibody, EPB41 antibody, el1 antibody, 4.1r antibody, 4.1R antibody, EL1 antibody, HE antibody, AI415518 antibody, D4Ertd442e antibody, Elp-1 antibody, Elp1 antibody, Epb41 antibody, mKIAA4056 antibody, erythrocyte membrane protein band 4.1b antibody, erythrocyte membrane protein band 4.1 antibody, erythrocyte membrane protein band 4.1 L homeolog antibody, epb41b antibody, EPB41 antibody, epb41 antibody, epb41.L antibody, Epb41 antibody

Background: Elliptocytosis is a hematologic disorder characterized by elliptically shaped erythrocytes and a variable degree of hemolytic anemia. Inherited as an autosomal dominant, elliptocytosis results from mutation in any one of several genes encoding proteins of the red cell membrane skeleton. The form discussed here is the one found in the 1950s to be linked to Rh blood group and more recently shown to be caused by a defect in protein 4.1. 'Rh-unlinked' forms of elliptocytosis are caused by mutation in the alpha-spectrin gene, the beta-spectrin gene, or the band 3 gene.Elliptocytosis is a hematologic disorder characterized by elliptically shaped erythrocytes and a variable degree of hemolytic anemia. Inherited as an autosomal dominant, elliptocytosis results from mutation in any one of several genes encoding proteins of the red cell membrane skeleton. The form discussed here is the one found in the 1950s to be linked to Rh blood group and more recently shown to be caused by a defect in protein 4.1. 'Rh-unlinked' forms of elliptocytosis are caused by mutation in the alpha-spectrin gene (MIM 182860), the beta-spectrin gene (MIM 182870), or the band 3 gene (MIM 109270).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-95 BM465039.1 1-95 96-2238 J03796.1 40-2182 2239-2780 AL833483.1 1799-2340 2781-2943 BU184161.1 560-722 2944-3952 AL833483.1 2504-3512 3953-4352 BM997767.1 226-625 4353-4796 BE257308.1 115-558 4797-5656 BC009063.1 442-1301 5657-6064 BM740451.1 1-408 c
Alias Symbols: 4.1R, EL1, HE
Protein Interaction Partner: CLNS1A, ZCCHC10, RWDD2B, CALM, UBC, FN1, Htt, MACROD1, C2CD2L, CENPJ, TJP2, EIF3G, SMAD3, SEC14L1, YWHAB, DLG1, KPNA2, CASK, GDI1, U2AF2, U2AF1, TUBA4A, TPM1, FKBP2, SPTB, SPTAN1, SPTBN1, EPB42, PRKCB, NUMA1, MYL1, YWHAQ, EGFR, DRD3, DRD2, CRYAB, BCAM, GY
Protein Size: 775

Molecular Weight: 85 kDa

Gene ID: 2035

NCBI Accession: NM_203343, NP_976218

UniProt: Q4VB86