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HDAC9 antibody (Middle Region)

HDAC9 Reactivity: Human, Rat, Mouse, Dog, Guinea Pig, Sheep, Cow, Horse, Rabbit, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2775579
  • Target See all HDAC9 Antibodies
    HDAC9 (Histone Deacetylase 9 (HDAC9))
    Binding Specificity
    • 18
    • 9
    • 9
    • 8
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 89
    • 26
    • 17
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Dog, Guinea Pig, Sheep, Cow, Horse, Rabbit, Zebrafish (Danio rerio)
    Host
    • 80
    • 9
    Rabbit
    Clonality
    • 72
    • 17
    Polyclonal
    Conjugate
    • 44
    • 8
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    This HDAC9 antibody is un-conjugated
    Application
    • 62
    • 47
    • 44
    • 32
    • 26
    • 9
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    GQVGAVKVKE EPVDSDEDAQ IQEMESGEQA AFMQQVIGKD LAPGFVIKVI
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 100%
    Characteristics
    This is a rabbit polyclonal antibody against HDAC9. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human HDAC9
    Top Product
    Discover our top product HDAC9 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 590 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Su, Becker, Kozyrskyj, Hayglass: "Epigenetic regulation of established human type 1 versus type 2 cytokine responses." in: The Journal of allergy and clinical immunology, Vol. 121, Issue 1, pp. 57-63.e3, (2008) (PubMed).

  • Target
    HDAC9 (Histone Deacetylase 9 (HDAC9))
    Alternative Name
    HDAC9 (HDAC9 Products)
    Synonyms
    HD7 antibody, HD7b antibody, HD9 antibody, HDAC antibody, HDAC7 antibody, HDAC7B antibody, HDAC9B antibody, HDAC9FL antibody, HDRP antibody, MITR antibody, AV022454 antibody, D030072B18Rik antibody, HD7B antibody, Hdac7b antibody, Mitr antibody, mKIAA0744 antibody, hdac9 antibody, zgc:73392 antibody, TWIST antibody, HDAC9 antibody, DKFZp459E171 antibody, HDA09 antibody, HISTONE DEACETYLASE antibody, histone deacetylase 9 antibody, RGD1310748 antibody, RGD1563092 antibody, hdac9-A antibody, histone deacetylase 9 antibody, histone deacetylase 9b antibody, histone deacetylase 9 S homeolog antibody, HDAC9 antibody, Hdac9 antibody, hdac9b antibody, HDA9 antibody, hdac9.S antibody
    Background
    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC9 has sequence homology to members of the histone deacetylase family. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. HDAC9 may play a role in hematopoiesis. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.
    Alias Symbols: DKFZp779K1053, HD7, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, KIAA0744, MITR, HD9, HD7b
    Protein Interaction Partner: NOP2, MKI67, EIF6, RCC1, ADAR, TOP1, TMPO, FIP1L1, CCAR2, TPX2, RBM14, ZC3H11A, HDAC9, NUP93, SMC3, H1FX, TPR, HINT1, CTBP1, BCL6, Zfp521, TRIM29, TP53, MAML1, SMARCA4, PARP1, CEBPB, H3F3A, RL2, CAMK1, YWHAE, HDAC1, SFN, MEF2B, ANKRA2, RFXANK, PKD1, SYK,
    Protein Size: 590
    Molecular Weight
    66 kDa
    Gene ID
    9734
    NCBI Accession
    NM_014707, NP_055522
    UniProt
    A7E2F3
    Pathways
    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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