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RGS18 antibody (N-Term)

RGS18 Reactivity: Human, Rat, Mouse, Dog, Guinea Pig, Horse, Cow, Rabbit WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2775584
  • Target See all RGS18 Antibodies
    RGS18 (Regulator of G-Protein Signalling 18 (RGS18))
    Binding Specificity
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    Human, Rat, Mouse, Dog, Guinea Pig, Horse, Cow, Rabbit
    Host
    • 10
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 13
    • 1
    Polyclonal
    Conjugate
    • 10
    • 2
    • 1
    • 1
    This RGS18 antibody is un-conjugated
    Application
    • 9
    • 7
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    METTLLFFSQ INMCESKEKT FFKLIHGSGK EETSKEAKIR AKEKRNRLSL
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against RGS18. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human RGS18
    Top Product
    Discover our top product RGS18 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 235 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    RGS18 (Regulator of G-Protein Signalling 18 (RGS18))
    Alternative Name
    RGS18 (RGS18 Products)
    Synonyms
    RGS18 antibody, rgs18 antibody, RGS13 antibody, regulator of G-protein signaling 18 antibody, regulator of G protein signaling 18 antibody, RGS18 antibody, rgs18 antibody, LOC100224724 antibody, Rgs18 antibody
    Background
    RGS18 is a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
    Alias Symbols: RP11-142L4.1, RGS13
    Protein Interaction Partner: APP, GNAQ, GNAI3, GNAI2, GNAI1,
    Protein Size: 235
    Molecular Weight
    26 kDa
    Gene ID
    64407
    NCBI Accession
    NM_130782, NP_570138
    UniProt
    Q9NS28
    Pathways
    Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling
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