Symplekin antibody (Middle Region)

Catalog No. ABIN2775624

Product Details anti-Symplekin Antibody

Target: Symplekin (SYMPK)

Binding Specificity: Middle Region

Reactivity: Human, Rat, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Symplekin antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GPLPKETAAG GLTLKEERSP QTLAPVGEDA MKTPSPAAED AREPEAKGNS

Predicted Reactivity: Human: 100%, Pig: 79%, Rat: 82%

Characteristics: This is a rabbit polyclonal antibody against SYMPK. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SYMPK

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1274 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Symplekin

Target: Symplekin (SYMPK)

Alternative Name: SYMPK (SYMPK Products)

Synonyms: SPK antibody, SYM antibody, CG2097 antibody, Dmel\\CG2097 antibody, dSymp antibody, 1500016F02Rik antibody, 4632415H16Rik antibody, AA125406 antibody, AI449890 antibody, Hfn3g antibody, sympk antibody, MGC75595 antibody, SYMPK antibody, T22C5.3 antibody, DKFZp468C0711 antibody, symplekin antibody, Symplekin antibody, symplekin S homeolog antibody, SYMPK antibody, Sym antibody, Sympk antibody, sympk.S antibody, sympk antibody, LOC552752 antibody, AT1G27595 antibody, LOC5580150 antibody, CpipJ_CPIJ011126 antibody, Bm1_50390 antibody, NAEGRDRAFT_80124 antibody, LOAG_00841 antibody

Background: SYMPK is a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ27092, SPK, SYM
Protein Interaction Partner: KAT6A, VCP, KMT2A, UBC, WWOX, RPA3, RPA2, RPA1, SSU72, CPSF2, CPSF3, TOP1, SUMO1, SIRT7, SUMO2, SMARCAD1, CSTF2, HTT, HSF1,
Protein Size: 1274

Molecular Weight: 141 kDa

Gene ID: 8189

NCBI Accession: NM_004819, NP_004810

UniProt: Q92797