HDAC8 antibody (C-Term)

Catalog No. ABIN2775890

Product Details anti-HDAC8 Antibody

Target: HDAC8 (Histone Deacetylase 8 (HDAC8))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Guinea Pig, Horse, Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC8 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TGVILGKTLS SEIPDHEFFT AYGPDYVLEI TPSCRPDRNE PHRIQQILNY

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against HDAC8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HDAC8

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 377 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HDAC8

Target: HDAC8 (Histone Deacetylase 8 (HDAC8))

Alternative Name: HDAC8 (HDAC8 Products)

Synonyms: HD8 antibody, CDLS5 antibody, HDACL1 antibody, MRXS6 antibody, RPD3 antibody, WTS antibody, 2610007D20Rik antibody, RGD1562895 antibody, wu:fd19a02 antibody, zgc:66196 antibody, ATHDA8 antibody, HDA8 antibody, HISTONE DEACETYLASE 8 antibody, T27G7.14 antibody, T27G7_14 antibody, histone deacetylase 8 antibody, histone deacetylase 8 antibody, histone deacetylase 8 L homeolog antibody, CC1G_05302 antibody, hdac8 antibody, HDAC8 antibody, Hdac8 antibody, hdac8.L antibody, HDA08 antibody

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: HDACL1, RPD3, HD8, CDA07
Protein Interaction Partner: MDM1, HDAC8, ZSCAN2, CHCHD3, STAG2, SEC16A, CROCC, SMC3, CPNE3, SMC1A, TPM4, TPM3, SVIL, NUP98, MME, ADD3, SMG5, SMG6, HSP90AA1, HSPA4, HIST4H4, HIST3H3, UBC, PRKACA, HIST1H4A, HIST1H3A, ESRRA, ACTA1, RTN1, PPP1CC, CREB1, HIST2H4A, RUNX1T1, CBFA2T3, MDC1,
Protein Size: 377

Molecular Weight: 42 kDa

Gene ID: 55869

NCBI Accession: NM_018486, NP_060956

UniProt: Q9BY41

Pathways: Cellular Glucan Metabolic Process