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CBX3 antibody (Middle Region)

CBX3 Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2775974
  • Target See all CBX3 Antibodies
    CBX3 (Chromobox Homolog 3 (CBX3))
    Binding Specificity
    • 20
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 106
    • 69
    • 53
    • 9
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit
    Host
    • 79
    • 27
    • 2
    Rabbit
    Clonality
    • 71
    • 37
    Polyclonal
    Conjugate
    • 54
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    This CBX3 antibody is un-conjugated
    Application
    • 56
    • 31
    • 29
    • 27
    • 27
    • 20
    • 18
    • 15
    • 8
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    ELIEAFLNSQ KAGKEKDGTK RKSLSDSESD DSKSKKKRDA ADKPRGFARG
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against CBX3. It was validated on Western Blot and immunohistochemistry.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human CBX3
    Top Product
    Discover our top product CBX3 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 183 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    CBX3 (Chromobox Homolog 3 (CBX3))
    Alternative Name
    CBX3 (CBX3 Products)
    Synonyms
    HECH antibody, HP1-GAMMA antibody, HP1Hs-gamma antibody, Hp1-gamma antibody, HP1g antibody, M32 antibody, cbx3 antibody, cbx3a antibody, xhp1g antibody, wu:fb61b02 antibody, zgc:153397 antibody, chromobox 3 antibody, chromobox 3 L homeolog antibody, chromobox protein homolog 3 pseudogene antibody, chromobox homolog 3a (HP1 gamma homolog, Drosophila) antibody, CBX3 antibody, Cbx3 antibody, cbx3.L antibody, LOC100355282 antibody, cbx3a antibody
    Background
    At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. CBX3 binds DNA and is a component of heterochromatin. CBX3 also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of CBX3 may explain the association of heterochromatin with the inner nuclear membrane.At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
    Alias Symbols: HECH, HP1-GAMMA, HP1Hs-gamma
    Protein Interaction Partner: UBC, SUMO1, MDM2, EED, SUZ12, RNF2, WDR1, DCK, ADSS, THOP1, TALDO1, PTMS, OXCT1, IDH1, HSPE1, HECW2, PARK2, VHL, CHAF1A, AURKB, AURKA, EHMT2, FN1, TRIM39, HNF1A, CBX5, MDC1, TP53BP1, YWHAE, TNKS1BP1, H2AFY, ATXN7L2, CACNB4, BAHD1, CUL1, PCGF6, SIRT7, RYBP
    Protein Size: 183
    Molecular Weight
    21 kDa
    Gene ID
    11335
    NCBI Accession
    NM_016587, NP_057671
    UniProt
    Q13185
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