KLHL3 antibody (N-Term)

Catalog No. ABIN2776039

Product Details anti-KLHL3 Antibody

Target: KLHL3 (Kelch-Like 3 (KLHL3))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Dog, Rabbit, Horse, Zebrafish (Danio rerio), Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLHL3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: HMAKLMEHVR LPLLPRDYLV QTVEEEALIK NNNTCKDFLI EAMKYHLLPL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Yeast: 90%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against KLHL3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human KLHL3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KLHL3

Target: KLHL3 (Kelch-Like 3 (KLHL3))

Alternative Name: KLHL3 (KLHL3 Products)

Synonyms: 7530408C15Rik antibody, AI430941 antibody, EG627648 antibody, PHA2D antibody, RGD1565218 antibody, kelch like family member 3 antibody, kelch-like 3 antibody, kelch-like family member 3 antibody, KLHL3 antibody, Klhl3 antibody

Background: KLHL3 protein contains a poxvirus and zinc finger domain at the N-terminus and six tandem repeats (kelch repeats) at the C-terminus. At the amino acid level, KLHL3 shares 77 % similarity with Drosophila kelch and 89 % similarity with Mayven (KLHL2), another human kelch homolog. At least three isoforms are produced and may be the result of alternative promoter usage. The KLHL3 maps within the smallest commonly deleted segment in myeloid leukemias characterized by a deletion of 5q, however, no inactivating mutations of KLHL3 could be detected in malignant myeloid disorders with loss of 5q.
Protein Interaction Partner: WNK4, KLHL12, KLHL3, KEAP1, MORF4L2, CUL3, UBC, C6orf165, WNK3, WNK2, WNK1, RBX1, SLC12A3, ELAVL1, SYNCRIP, SYT2, OPRD1, GNAO1, GNAI1,
Protein Size: 505

Molecular Weight: 55 kDa

Gene ID: 26249