PKD2 antibody (N-Term)

Catalog No. ABIN2776087

Product Details anti-PKD2 Antibody

Target: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKD2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GLRGLWGTRL MEESSTNREK YLKSVLRELV TYLLFLIVLC ILTYGMMSSN

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PKD2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human PKD2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PKD2

Target: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Alternative Name: PKD2 (PKD2 Products)

Synonyms: APKD2 antibody, PC2 antibody, PKD4 antibody, Pc-2 antibody, TRPP2 antibody, C030034P18Rik antibody, RGD1559992 antibody, pkd2 antibody, trpp2 antibody, Cup antibody, PKD2L1 antibody, polycystin 2, transient receptor potential cation channel antibody, polycystic kidney disease 2 antibody, Polycystin-2 antibody, polycystin 2, transient receptor potential cation channel L homeolog antibody, PKD2 antibody, Pkd2 antibody, pkd-2 antibody, pkd2.L antibody, pkd2 antibody

Background: This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2.
Protein Interaction Partner: MAGEA8, PLSCR1, KRTAP10-3, KRTAP10-8, KRT40, PKD1, GOLGA2, CANX, ATP1A1, UBC, PACS2, HAX1, TRPC1, TNNI3, PACS1, CD2AP, DIAPH1, TPM1, PKD2, ACTN2,
Protein Size: 646

Molecular Weight: 71 kDa

Gene ID: 5311

Pathways: cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity