VDAC2 antibody (N-Term)

Catalog No. ABIN2776154

Product Details anti-VDAC2 Antibody

Target: VDAC2 (Voltage-Dependent Anion Channel 2 (VDAC2))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Dog, Cow, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio), Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VDAC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: MATHGQTCAR PMCIPPSYAD LGKAARDIFN KGFGFGLVKL DVKTKSCSGV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 79%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against VDAC2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human VDAC2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 294 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-VDAC2 antibody (ABIN2776154)

Hrabakova, Kollareddy, Tyleckova, Halada, Hajduch, Gadher, Kovarova: "Cancer cell resistance to aurora kinase inhibitors: identification of novel targets for cancer therapy." in: Journal of proteome research, Vol. 12, Issue 1, pp. 455-69, (2013) (PubMed).

Target Details for VDAC2

Target: VDAC2 (Voltage-Dependent Anion Channel 2 (VDAC2))

Alternative Name: VDAC2 (VDAC2 Products)

Background: VDAC2 forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.
Alias Symbols: RP11-375G3.1, FLJ23841, POR
Protein Interaction Partner: MDM2, ADRB2, FBXO6, PARK2, PHKG2, PHB, VCAM1, UBC, ITGA4, FN1, ATF2, env, MDC1, ECT2, ACAA2, TRAP1, ATP6V1F, VDAC3, VDAC1, UBE2L3, UBA52, SSBP1, SCP2, RPN1, MPV17, RPSA, HNRNPU, FLOT2, ELAVL1, DDOST, APP, Htt, ZNF454, SFXN3, THOC6, SUGP1, SEPT11, ZFR, ATP
Protein Size: 294

Molecular Weight: 32 kDa

Gene ID: 7417

NCBI Accession: NM_003375, NP_003366