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KCNMB4 antibody (Middle Region)

KCNMB4 Reactivity: Human, Mouse, Rat, Sheep, Rabbit, Cow, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2776204
  • Target See all KCNMB4 Antibodies
    KCNMB4 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 4 (KCNMB4))
    Binding Specificity
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 17
    • 10
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Sheep, Rabbit, Cow, Guinea Pig
    Host
    • 13
    • 6
    Rabbit
    Clonality
    • 15
    • 4
    Polyclonal
    Conjugate
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KCNMB4 antibody is un-conjugated
    Application
    • 9
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    TCGADCRGTS QYPCVQVYVN NSESNSRALL HSDEHQLLTN PKCSYIPPCK
    Predicted Reactivity
    Cow: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Sheep: 100%
    Characteristics
    This is a rabbit polyclonal antibody against KCNMB4. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human KCNMB4
    Top Product
    Discover our top product KCNMB4 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 210 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    KCNMB4 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 4 (KCNMB4))
    Alternative Name
    KCNMB4 (KCNMB4 Products)
    Synonyms
    1700058G18Rik antibody, 2900045G12Rik antibody, kcnmb4 antibody, potassium calcium-activated channel subfamily M regulatory beta subunit 4 antibody, potassium large conductance calcium-activated channel, subfamily M, beta member 4 antibody, potassium channel subfamily M regulatory beta subunit 4 antibody, Kcnmb4 antibody, KCNMB4 antibody, kcnmb4 antibody
    Background
    KCNMB4 is the regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. KCNMB4 modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. KCNMB4 decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. KCNMB4 may decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. KCNMB4 makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit.
    Alias Symbols: -
    Protein Size: 210
    Molecular Weight
    24 kDa
    Gene ID
    27345
    NCBI Accession
    NM_014505, NP_055320
    UniProt
    Q86W47
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