CLCN6 antibody (C-Term)

Catalog No. ABIN2776242

Product Details anti-CLCN6 Antibody

Target: CLCN6 (Chloride Channel, Voltage-Sensitive 6 (CLCN6))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Cow, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLCN6 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PQFQSISLRK IQFNFPYFRS DRDKRDFVSA GAAAGVAAAF GAPIGGTLFS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against CLCN6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CLCN6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 353 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-CLCN6 antibody (ABIN2776242)

Jensen, Nosjean, Dziegiel, Boutin, Sørensen, Karsdal, Henriksen: "A quantitative assay for lysosomal acidification rates in human osteoclasts." in: Assay and drug development technologies, Vol. 9, Issue 2, pp. 157-64, (2011) (PubMed).

Tran, Leclerc, Chan, Pai, Hiou-Tim, Wu, Goyette, Artigas, Milos, Rozen: "Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 13, Issue 9, pp. 483-92, (2002) (PubMed).

Target Details for CLCN6

Target: CLCN6 (Chloride Channel, Voltage-Sensitive 6 (CLCN6))

Alternative Name: CLCN6 (CLCN6 Products)

Synonyms: CLC-6 antibody, AI850629 antibody, CLCN6 antibody, wu:fb95f01 antibody, DKFZp469B244 antibody, DKFZp469L0417 antibody, chloride voltage-gated channel 6 antibody, chloride channel, voltage-sensitive 6 antibody, chloride channel 6 antibody, chloride transport protein 6 antibody, CLCN6 antibody, Clcn6 antibody, clcn6 antibody, LOC579870 antibody

Background: The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB.
Alias Symbols: CLC-6
Protein Interaction Partner: UBC, PPP2R1A,
Protein Size: 353

Molecular Weight: 39 kDa

Gene ID: 1185

NCBI Accession: NM_021736, NP_068504

UniProt: Q5SNX3