KCND3 antibody (Middle Region)

Catalog No. ABIN2776308

Product Details anti-KCND3 Antibody

Target: KCND3 (Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 (KCND3))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Guinea Pig, Horse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCND3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VAKTGSSNAY LHSKRNGLLN EALELTGTPE EEHMGKTTSL IESQHHHLLH

Predicted Reactivity: Cow: 100%, Dog: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against KCND3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KCND3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 636 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KCND3

Target: KCND3 (Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 (KCND3))

Alternative Name: KCND3 (KCND3 Products)

Synonyms: KCND3 antibody, zgc:55306 antibody, wu:fi06g01 antibody, kv4.3 antibody, K(v)4.3 antibody, AW045978 antibody, Kncd3 antibody, Kv4.3 antibody, KCND3L antibody, KCND3S antibody, KSHIVB antibody, KV4.3 antibody, kcnd3-A antibody, xKv4.3 antibody, potassium voltage-gated channel subfamily D member 3 antibody, potassium voltage-gated channel, Shal-related subfamily, member 3 antibody, potassium channel, voltage gated Shal related subfamily D, member 3 antibody, potassium voltage-gated channel, Shal-related family, member 3 antibody, potassium channel, voltage gated Shal related subfamily D, member 3 L homeolog antibody, KCND3 antibody, kcnd3 antibody, Kcnd3 antibody, kcnd3.L antibody

Background: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). KCND3 encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene.
Alias Symbols: KCND3L, KCND3S, KSHIVB, KV4.3, MGC142035, MGC142037
Protein Interaction Partner: NDUFS2, NAP1L1, LBR, HSPA8, HSPA5, HNRNPF, XRCC6, EWSR1, EMD, DDB1, CUX1, CDK1, AUP1, NONO, XRCC5, UQCRC2, TUBB2A, RCN2, Rapgef5, Rapgef4, Kcnip1, Rapgef3, Kcnip2, DPP10, PYCR2, VPS4A, TUBA1B, G3BP1, RUVBL1, CNBP, SRC, KCND3,
Protein Size: 636

Molecular Weight: 71 kDa

Gene ID: 3752

NCBI Accession: NM_172198, NP_751948

UniProt: Q14D71