KLF6 antibody (Middle Region)

Catalog No. ABIN2776377

Product Details anti-KLF6 Antibody

Target: KLF6 (Kruppel-Like Factor 6 (KLF6))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Horse, Rabbit, Guinea Pig, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLF6 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SREPSQLWGC VPGELPSPGK VRSGTSGKPG DKGNGDASPD GRRRVHRCHF

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against KLF6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KLF6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 283 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KLF6

Target: KLF6 (Kruppel-Like Factor 6 (KLF6))

Alternative Name: KLF6 (KLF6 Products)

Synonyms: gbf antibody, zf9 antibody, bcd1 antibody, cba1 antibody, cpbp antibody, pac1 antibody, st12 antibody, copeb antibody, MGC53475 antibody, KLF6 antibody, MGC127307 antibody, BCD1 antibody, CBA1 antibody, COPEB antibody, CPBP antibody, GBF antibody, PAC1 antibody, ST12 antibody, ZF9 antibody, AI448727 antibody, C86813 antibody, Copeb antibody, FM2 antibody, FM6 antibody, Ierepo1 antibody, Ierepo3 antibody, R75280 antibody, Zf9 antibody, Aa1017 antibody, klf6 antibody, cb538 antibody, wu:fb76d04 antibody, wu:fb92h03 antibody, wu:fe26g06 antibody, wu:fk78f12 antibody, Kruppel-like factor 6 L homeolog antibody, Kruppel like factor 6 antibody, Krueppel-like factor 6 antibody, Kruppel-like factor 6 antibody, Kruppel-like factor 6 S homeolog antibody, Kruppel-like factor 6a antibody, klf6.L antibody, KLF6 antibody, LOC100196412 antibody, klf6 antibody, Klf6 antibody, klf6.S antibody, klf6a antibody

Background: KLF6 is a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. KLF6 may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes.This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. Two transcript variants encoding the same protein have been found for this gene.
Alias Symbols: GBF, ZF9, BCD1, CBA1, CPBP, PAC1, ST12, COPEB
Protein Interaction Partner: UBC, APP, LCOR, SP1, NUFIP1, NOP56, TAF9, FBL, HDAC3, E2F1, NR0B2, PNO1, POLA2, GTF3C1, EHMT2, APOM, CELSR2, KLF4, TP53, CCND1,
Protein Size: 283

Molecular Weight: 32 kDa

Gene ID: 1316

NCBI Accession: NM_001300, NP_001291

UniProt: Q99612