MTA2 antibody (N-Term)

Catalog No. ABIN2776428

Product Details anti-MTA2 Antibody

Target: MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Horse, Goat, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTA2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NGNVEAKVVC LFRRRDISSS LNSLADSNAR EFEEESKQPG VSEQQRHQLK

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against MTA2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MTA2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 668 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MTA2

Target: MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))

Alternative Name: MTA2 (MTA2 Products)

Synonyms: MTA1L1 antibody, PID antibody, fd61b05 antibody, wu:fd61b05 antibody, wu:fi29g02 antibody, zgc:63487 antibody, pid antibody, mta1l1 antibody, MTA2 antibody, DKFZp470E0911 antibody, AW550797 antibody, Mata1l1 antibody, Mta1l1 antibody, mmta2 antibody, metastasis associated 1 family member 2 antibody, metastasis associated 1 family, member 2 antibody, metastasis-associated gene family, member 2 antibody, metastasis associated 1 family member 2 L homeolog antibody, MTA2 antibody, mta2 antibody, Mta2 antibody, mta2.L antibody

Background: MTA2 may be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: DKFZp686F2281, MTA1L1, PID
Protein Interaction Partner: vpr, SUMO2, SUMO3, DNMT3B, DNMT1, NACC2, ZBTB16, UBC, RARA, ZBTB1, RNF2, GPHN, HNRNPR, TRIM28, PPP4R1, ROCK2, SPAG9, POLR2C, POLR2A, MAP4, RPP25, LSM8, GET4, LARP7, CD2AP, NR3C1, MTOR, EHBP1L1, RABEP2, BRCC3, SMEK1, ZGPAT, HDAC1, HDAC2, CSNK1E, MTA3, UBE3
Protein Size: 668

Molecular Weight: 75 kDa

Gene ID: 9219

NCBI Accession: NM_004739, NP_004730

UniProt: O94776

Pathways: Chromatin Binding