MAGEA9 antibody (Middle Region)

Catalog No. ABIN2776439

Product Details anti-MAGEA9 Antibody

Target: MAGEA9 (Melanoma Antigen Family A, 9 (MAGEA9))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Dog, Horse, Rabbit, Cow, Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAGEA9 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ALKLKVAELV HFLLHKYRVK EPVTKAEMLE SVIKNYKRYF PVIFGKASEF

Predicted Reactivity: Cow: 77%, Dog: 79%, Horse: 79%, Human: 100%, Pig: 79%, Rabbit: 85%, Rat: 85%, Yeast: 77%

Characteristics: This is a rabbit polyclonal antibody against MAGEA9. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MAGEA9

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 315 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAGEA9

Target: MAGEA9 (Melanoma Antigen Family A, 9 (MAGEA9))

Alternative Name: MAGEA9 (MAGEA9 Products)

Synonyms: CT1.9 antibody, MAGE9 antibody, MAGEA9B antibody, MAGEA9 antibody, MAGE family member A9 antibody, melanoma antigen family A, 9B antibody, melanoma-associated antigen 9 antibody, MAGEA9 antibody, MAGEA9B antibody, LOC525400 antibody

Background: MAGEA9 is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80 % sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This pseudogene is a member of the cytochrome P450 gene superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. It is possible that, in rare cases, a combination of two SNPs in this gene may result in an open reading frame encoding a functional enzyme which metabolizes codeine to morphine. This locus is part of a cluster of cytochrome P450 genes on chromosome 22q13.1. This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80 % sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.
Alias Symbols: MAGE9, MGC8421, CT1.9, MAGEA9B
Protein Interaction Partner: APPL1, UBC, EGLN1,
Protein Size: 315

Molecular Weight: 35 kDa

Gene ID: 4108

NCBI Accession: NM_005365, NP_005356

UniProt: P43362