MBNL2 antibody (Middle Region)

Catalog No. ABIN2776541

Product Details anti-MBNL2 Antibody

Target: MBNL2 (Muscleblind-Like 2 (MBNL2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBNL2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IACFDSLKGR CSRENCKYLH PPTHLKTQLE INGRNNLIQQ KTAAAMLAQQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against Mbnl2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of RAT Mbnl2

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MBNL2

Target: MBNL2 (Muscleblind-Like 2 (MBNL2))

Alternative Name: Mbnl2 (MBNL2 Products)

Synonyms: 1110002M11Rik antibody, AI047808 antibody, AI837313 antibody, AI849185 antibody, AL118326 antibody, MBLL antibody, R75232 antibody, mKIAA4072 antibody, wu:fj89c04 antibody, MBLL39 antibody, PRO2032 antibody, muscleblind like splicing factor 2 antibody, muscleblind-like splicing regulator 2 antibody, muscleblind like splicing regulator 2 antibody, Mbnl2 antibody, mbnl2 antibody, MBNL2 antibody

Background: Mbnl2 mediates pre-mRNA alternative splicing regulation. It acts either as activator or repressor of splicing on specific pre-mRNA targets. It inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. It antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. It binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. It seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. It may play a role in myotonic dystrophy pathophysiology (DM).
Protein Size: 378

Molecular Weight: 41 kDa

Gene ID: 680445

UniProt: F2Z3T4