SRSF10 antibody (C-Term)

Catalog No. ABIN2776611

Product Details anti-SRSF10 Antibody

Target: SRSF10 (serine/arginine-Rich Splicing Factor 10 (SRSF10))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Guinea Pig, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRSF10 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: TDSKTHYKSG SRYEKESRKK EPPRSKSQSR SQSRSRSKSR SRSWTSPKSS

Predicted Reactivity: Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against FUSIP1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human FUSIP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 262 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SRSF10

Target: SRSF10 (serine/arginine-Rich Splicing Factor 10 (SRSF10))

Alternative Name: FUSIP1 (SRSF10 Products)

Background: FUSIP1 is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing.This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing. Alternative splicing of this gene results in at least two transcript variants encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist.
Alias Symbols: FUSIP2, NSSR, SFRS13, SRp38, SRrp40, TASR, TASR1, TASR2, FUSIP1, SFRS13A
Protein Interaction Partner: STAU1, WWOX, SUZ12, EED, RNF2, EZH2, HECW2, TRA2B, SRSF4, SRSF1, CSNK2A1, EIF4A3, MAGOH, PAXIP1, BARD1, SAP18, VTN, TCOF1, SRSF6, S100A9, PRKDC, NHP2L1, NFIA, SEPT2, MSH2, IK, EPRS, DHX15, BCAS2, TRIM55, THOC6, ZNF687, SMU1, TRMT112, TRA2A, PHGDH, NCSTN,
Protein Size: 262

Molecular Weight: 29 kDa

Gene ID: 10772

NCBI Accession: NM_054016, NP_473357

UniProt: O75494

Pathways: Ribonucleoprotein Complex Subunit Organization