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Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX) antibody (FITC)

Details for Product No. ABIN277662, Supplier: Log in to see
Antigen
  • AI449405
  • Cd11c
  • Cr4
  • N418
  • Itgax
  • RGD1561123
  • CD11C
  • SLEB6
Reactivity
Mouse (Murine)
320
165
62
22
10
7
2
2
1
Host
Armenian Hamster
285
101
86
27
6
3
Clonality (Clone)
Monoclonal ()
Conjugate
FITC
60
51
50
30
12
10
9
9
8
7
6
6
6
5
5
4
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
361
82
79
78
67
53
48
36
11
10
9
9
7
7
7
5
5
4
3
2
1
1
1
1
1
1
1
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Clone N418
Isotype IgG
Specificity The N418 monoclonal antibody reacts with mouse CD11c, the integrin αX. CD11c non-covalently associates with β2 integrin to form the CD11c/CD18 heterodimer. CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some activated T cells. CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. N418 binds to CD11c on splenic dendritic cells in the T-dependent areas of mouse spleen and precipitates a 150, 90 kDa heterodimer.
Characteristics The N418 monoclonal antibody reacts with mouse CD11c, the integrin αX. CD11c non-covalently associates with β2 integrin to form the CD11c/CD18 heterodimer. CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some activated T cells. CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. N418 binds to CD11c on splenic dendritic cells in the T-dependent areas of mouse spleen and precipitates a 150, 90 kDa heterodimer.
Synonyms: Synonyms: Integrin alpha X, p150/95,
Alternative Name CD11c (ITGAX Antibody Abstract)
Background CD11c non-covalently associates with beta2 integrin to form the CD11c/CD18 heterodimer. CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some, Mouse
Research Area Stem Cells, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells
Application Notes Applications reported: The N418 antibody has been reported for use in flow cytometric analysis.

Applications tested: The N418 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Comment

Excitation/Emission wavelength: 494 nm/514 nm

Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer aqueous buffer, 0.09 % sodium azide, may contain carrier protein/stabilizer
Handling Advice Do not freeze. Light sensitive material.
Storage 4 °C
Supplier Images
 image for anti-Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX) antibody (FITC) (ABIN277662) Staining of C57Bl/6 splenocytes with APC anti -CD45R/B220 (RA3 -6B2)(cat.17 -0452) an...
 image for anti-Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX) antibody (FITC) (ABIN277662) anti-Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX) antibody (FITC) (Image 2)
Background publications Kaplan, Li, Jenison et al.: "Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells." in: The Journal of experimental medicine, Vol. 204, Issue 11, pp. 2545-52, 2007 (PubMed).